1/15
Read
30 min?
W00
Craft
Richard W. Hamming, You and Your Research, Bell Communications Research Colloquium, 7 March 1986…
Spare pocket 1
It is the argument for why a 40-week plan aimed at one thesis beats 40 weeks of interesting side quests — the exact failure mode your ADHD brain is best at
Read exactly: The passage on "important problems" (why most scientists never work on one) and the passage on open door vs closed door
Produce: 5 lines in notes/craft/W00.md: the one important problem you are choosing, and the two you are refusing
In: LABLOOP-W00 Notebook
2/15
Read
30 min?
W00
Craft
Uri Alon, "How To Choose a Good Scientific Problem", Molecular Cell 35(6):726-728, 2009. DOI 10.…
Spare pocket 2
You will reuse that chart in week 21 to scope Paper 3 with a partner. Learn it now, cheaply
Read exactly: Whole paper, 2 pages — especially the feasibility × interest chart
Produce: Place FermLit on the feasibility/interest chart, one paragraph, into notes/craft/W00.md
In: LABLOOP-W00 Notebook
3/15
Read
30 min?
W00
Craft
Wilson G. et al., "Good enough practices in scientific computing", PLOS Computational Biology 13…
Spare pocket 3
Justifies, in one sitting, every folder you create today (data/raw read-only and never committed, reports/figures regenerated)
Read exactly: Sections "Data management" and "Project organization" only
Produce: Copy the two directory checklists into the README skeletons of batchlens and fermlit
In: LABLOOP-W00 Notebook
8/15
Watch
18 min
W00
Sunday
Craft
Barbara Oakley · "Learning how to learn"
Sunday, before writing post 0
· Sunday, before writing post 0
Produce: One line in notes/craft/W00.md: which ritual in Part 0.3 is your diffuse-mode slot
In: LABLOOP-W00 Notebook
9/15
Watch
60 min
W00
Sunday
Craft
Richard Hamming · "You and Your Research"
Sunday, before writing post 0
· after Barbara Oakley · "Learning how to learn"
· Only if you prefer voice to text — it replaces R1, it does not add to it. Play at 1.25× while packing the cockpit
Produce: Same output as R1
In: LABLOOP-W00 Notebook
10/15
Watch
40 min
W00
Craft
Learning How to Learn
Any block this week
· Optional substitute for V1 if you want the full treatment
Produce: Nothing. Do not enrol in the whole course
In: LABLOOP-W00 Notebook
11/15
Read
30 min?
W00
Craft
The Turing Way handbook
Your week-4 DOI release and week-36 JOSS submission are graded against exactly these habits
Read exactly: "Guide for Reproducible Research" → the overview chapter only; browse the table of contents
Produce: Two checklists saved to PARKING.md, not acted on yet
In: LABLOOP-W00 Notebook
1/18
Watch
6 min
W01
Monday
Craft
LearnChemE (CU Boulder) · "Monod Cell Growth Example (Bio)"
Monday build block
· Monday, before coding
Produce: A hand-sketched growth curve taped next to the screen
In: LABLOOP-W01 Notebook
2/18
Read
30 min?
W01
Monday
Craft
SciPy docs, scipy.integrate.solve_ivp
Monday build block
· after LearnChemE (CU Boulder) · "Monod Cell Growth Example (Bio)"
Replace predator-prey with biomass-substrate and Monday's task is mostly done
Read exactly: The Examples section only, especially the Lotka-Volterra style system
Produce: The working ODE skeleton in batchlens/sim/monod.py
In: LABLOOP-W01 Notebook
3/18
Read
30 min?
W01
Tuesday
Craft
OpenStax Biology 2e, 6.5 Enzymes
Tuesday · B1
Enzyme + substrate is literally the shape of the Monod term S/(Ks+S) you code on Monday
Read exactly: Whole section, plus the chapter-6 review questions reachable from Ch. 6 Introduction if time allows
Produce: 5 questions at the end of notes/bio/B1.md; answer them yourself next week
In: LABLOOP-W01 Notebook
4/18
Read
30 min?
W01
Wednesday
Craft
eclipse-paho/paho.mqtt.python README
Wednesday build block
Wednesday's telemetry hop, nothing more
Read exactly: "Publish a single message" example
Produce: The publisher in the Wednesday artifact
In: LABLOOP-W01 Notebook
5/18
Watch
30 min
W01
Thursday
Craft
3Blue1Brown · Essence of Linear Algebra
Thursday · M1
· Thursday, first
Produce: notes/ml/M1.md: what a matrix does to a vector; one example redone in NumPy
In: LABLOOP-W01 Notebook
1/15
Read
30 min?
W02
Monday
Craft
Goldrick S. et al., "The development of an industrial-scale fed-batch fermentation simulation",…
Monday build block
· Read it inside Monday's build block
This is the paper behind the dataset you are tidying. Paper 2 will cite it
Read exactly: Abstract, all figures, and section 2 (the model)
Produce: Five lines in notes/bio/B2.md: which state variables the simulator actually integrates
In: LABLOOP-W02 Notebook
2/15
Watch
13 min
W02
Tuesday
Craft
Crash Course Biology #7 · "ATP & Respiration"
Tuesday · B2
· Tuesday, first
Produce: Three lines in notes/bio/B2.md: why DO falls when biomass grows
In: LABLOOP-W02 Notebook
3/15
Read
30 min?
W02
Wednesday
Craft
Goldrick S. et al., "Modern day monitoring and control challenges outlined on an industrial-scal…
Wednesday build block
Your whole week-03 alarm evaluation depends on knowing which batches are the faulty ones — and on the licence for redistribution
Read exactly: Abstract + the dataset section: how many batches, which are faulty, how faults are labelled, what the Raman block is
Produce: A variable table (name, unit, online/offline) and the fault list, with quoted sentences and their page numbers
In: LABLOOP-W02 Notebook
4/15
Watch
25 min
W02
Thursday
Craft
3Blue1Brown · Essence of Calculus
Thursday · M2
· Thursday
Produce: notes/ml/M2.md: what a derivative is, in your own words
In: LABLOOP-W02 Notebook
5/15
Watch
22 min
W02
Thursday
Craft
StatQuest · "Principal Component Analysis (PCA), Step-by-Step"
Thursday · M2
· after 3Blue1Brown · Essence of Calculus
· Before Friday's PCA code
Produce: The 3-line explanation of scores vs loadings you will paste into Sunday's post
In: LABLOOP-W02 Notebook
1/20
Read
30 min?
W03
Monday
Craft
NIST/SEMATECH e-Handbook of Statistical Methods
Monday build block
The public, citable reference for the limits you compute on Monday. Phase I vs Phase II is the distinction that stops you fooling yourself
Read exactly: 6.3.4 What are multivariate control charts? → 6.5.4.3 Hotelling's T² → 6.5.4.3.6 Constructing multivariate charts
Produce: The limit formula, with its source URL, in a comment above the code that implements it
In: LABLOOP-W03 Notebook
2/20
Read
30 min?
W03
Monday
Craft
NIST/SEMATECH e-Handbook ch. 6.5 "Tutorials: multivariate control charts"
Monday build block
· after NIST/SEMATECH e-Handbook of Statistical Methods
· Read it inside Monday's build block
Build-block reading · NIST/SEMATECH e-Handbook ch. 6.5 "Tutorials: multivariate control charts" — https://www.itl.nist.gov/div898/handbook/pmc/section3/pmc34.htm (sections 6.3.4 and 6.5.4.3)
In: LABLOOP-W03 Notebook
3/20
Read
30 min?
W03
Tuesday
Craft
OpenStax Microbiology, ch. 9 "Microbial Growth"
Tuesday · B3
You will discover your week-01 Monod model already explains the log phase — and what it does not explain
Read exactly: The growth-curve section only (lag, log, stationary, death). Oxygen, temperature and pH are parked
Produce: notes/bio/B3.md + a hand-drawn growth curve photographed into the notes
In: LABLOOP-W03 Notebook
4/20
Read
30 min?
W03
Wednesday
Craft
erdogant/pca README
Wednesday build block
A second implementation to compare against. Compare numbers, never copy them without understanding
Read exactly: The Hotelling T² / SPE outlier section
Produce: One line in review.md: do your limits agree with theirs, and if not, why
In: LABLOOP-W03 Notebook
5/20
Watch
17 min
W03
Thursday
Craft
3Blue1Brown · "Eigenvectors and eigenvalues"
Thursday · M3
· Thursday, first
Produce: One sentence in notes/ml/M3.md: what last Friday's principal components actually are
6/20
Watch
7 min
W03
Thursday
Craft
StatQuest · "Machine Learning Fundamentals: Bias and Variance"
Thursday · M3
· after 3Blue1Brown · "Eigenvectors and eigenvalues"
· Thursday, after V4
Produce: The bias-variance sentence in notes/ml/M3.md
In: LABLOOP-W03 Notebook
7/20
Watch
13 min
W03
Thursday
Craft
StatQuest · "Linear Regression, Clearly Explained!!!"
Thursday · M3
· after StatQuest · "Machine Learning Fundamentals: Bias and Variance"
· Thursday, after V2
Produce: One regression fitted on two IndPenSim variables and read aloud: slope, intercept, what it means
In: LABLOOP-W03 Notebook
1/17
Watch
10 min
W04
Tuesday
Craft
Khan Academy · "Fermentation and anaerobic respiration"
Tuesday · B4
· Tuesday, first
Produce: One paragraph in notes/bio/B4.md: "what is a fermentation, really"
In: LABLOOP-W04 Notebook
2/17
Read
30 min?
W04
Wednesday
Craft
GitHub Docs, "Referencing and citing content" and "About CITATION files"; format spec at citatio…
Wednesday build block
This is the literal procedure for Friday's DOI badge. Read it once, follow it exactly
Read exactly: The Zenodo-integration steps and the minimal CITATION.cff fields
Produce: CITATION.cff in the repo root and a rendering DOI badge in the README
In: LABLOOP-W04 Notebook
3/17
Watch
6 min
W04
Thursday
Craft
StatQuest · "Machine Learning Fundamentals: Cross Validation"
Thursday · M4
· Thursday, first
Produce: The sentence "why random k-fold is wrong for batch data" in notes/ml/M4.md
In: LABLOOP-W04 Notebook
4/17
Read
30 min?
W04
Thursday
Craft
Kapoor S. & Narayanan A., "Leakage and the reproducibility crisis in machine-learning-based scie…
Thursday · M4
· after StatQuest · "Machine Learning Fundamentals: Cross Validation"
The single best paper on the exact mistake that would invalidate Paper 2. Cite it in week 08 and week 18
Read exactly: The taxonomy of eight leakage types; identify which one batch-wise CV prevents
Produce: One paragraph in the README's honest "Where it fails" section naming the leakage type you guarded against
In: LABLOOP-W04 Notebook
1/16
Read
30 min?
W05
Monday
Craft
Europe PMC REST API docs
Monday build block
· Read it inside Monday's build block
Build-block reading · Europe PMC REST API docs — europepmc.org/RestfulWebService (search syntax, OPEN_ACCESS:y, fullTextXML)
In: LABLOOP-W05 Notebook
11/16
Watch
25 min
W05
Craft
StatQuest "Regularization Part 1: Ridge (L2) Regression"
StatQuest "Regularization Part 1: Ridge (L2) Regression" and "Gradient Boost Part 1: Regression Main Ideas" (YouTube, 25 min)
In: LABLOOP-W05 Notebook
1/12
Read
30 min?
W06
Monday
Craft
Datasheets for Datasets: Gebru et al.
Monday build block
· Read it inside Monday's build block
Build-block reading · Datasheets for Datasets: Gebru et al. (2021), Communications of the ACM 64(12):86-92. The questions your guidelines and dataset card must answer
In: LABLOOP-W06 Notebook
1/12
Read
30 min?
W07
Monday
Craft
Zheng et al. (2023), "Judging LLM-as-a-judge with MT-Bench and Chatbot Arena"
Monday build block
· Read it inside Monday's build block
Build-block reading · Zheng et al. (2023), "Judging LLM-as-a-judge with MT-Bench and Chatbot Arena", NeurIPS Datasets & Benchmarks, sections 1-3 (judge biases you must avoid in week 14)
In: LABLOOP-W07 Notebook
1/15
Run
30 min?
W08
Monday
Craft
Luttmann et al. (2012), "Soft sensors in bioprocessing: a status report and recommendations"
Monday build block
· Read it inside Monday's build block
Build-block reading · Luttmann et al. (2012), "Soft sensors in bioprocessing: a status report and recommendations", Biotechnology Journal 7(8):1040-1048. The reference framing for your soft-sensor section
In: LABLOOP-W08 Notebook
1/11
Read
30 min?
W10
Monday
Craft
McHugh
Monday build block
· Read it inside Monday's build block
Build-block reading · McHugh (2012) kappa paper (carry over from week 6), results interpretation table
In: LABLOOP-W10 Notebook
1/12
Read
30 min?
W11
Monday
Craft
Hugging Face "Dataset Cards" documentation
Monday build block
· Read it inside Monday's build block
Build-block reading · Hugging Face "Dataset Cards" documentation (huggingface.co/docs/hub/datasets-cards)
In: LABLOOP-W11 Notebook
1/12
Read
30 min?
W12
Monday
Craft
Brunton, Proctor & Kutz
Monday build block
· Read it inside Monday's build block
Build-block reading · Brunton, Proctor & Kutz (2016), "Discovering governing equations from data by sparse identification of nonlinear dynamical systems", PNAS 113(15):3932-3937 (abstract + figure 1)
In: LABLOOP-W12 Notebook
1/13
Read
30 min?
W13
Monday
Craft
Mensh & Kording (2017), "Ten simple rules for structuring papers"
Monday build block
· Read it inside Monday's build block
Build-block reading · Mensh & Kording (2017), "Ten simple rules for structuring papers", PLoS Computational Biology 13(9):e1005619
In: LABLOOP-W13 Notebook
8/12
Read
30 min?
W14
Craft
Writing · Coursera Writing in the Sciences
Writing · Coursera Writing in the Sciences (Stanford), modules 1-2 (cutting clutter, active voice) — watch at 1.5x during Saturday buffer if needed
In: LABLOOP-W14 Notebook
1/14
Read
30 min?
W16
Monday
Craft
bioRxiv submission guide
Monday build block
· Read it inside Monday's build block
Build-block reading · bioRxiv submission guide (biorxiv.org/submit-a-manuscript)
In: LABLOOP-W16 Notebook
8/13
Watch
15 min?
W17
Craft
StatQuest "Ridge vs Lasso Regression, Visualized!!!"
StatQuest "Ridge vs Lasso Regression, Visualized!!!" (YouTube) for the head you fit
In: LABLOOP-W17 Notebook
7/10
Watch
30 min
W19
Craft
StatQuest "PCA main ideas", "t-SNE, Clearly Explained" and "UMAP Dimension Reduction, Main Ideas…
StatQuest "PCA main ideas", "t-SNE, Clearly Explained" and "UMAP Dimension Reduction, Main Ideas!!!" (YouTube, 30 min) — the three plots every single-cell talk shows
In: LABLOOP-W19 Notebook
7/10
Watch
60 min
W20
Craft
Patrick Winston, "How to Speak"
Patrick Winston, "How to Speak" (MIT OCW / YouTube, ~1 h) — watch Saturday; it prepares both the mock sessions and the talk proposal
In: LABLOOP-W20 Notebook
7/13
Read
15 min
W21
Craft
Uri Alon (2009), "How to choose a good scientific problem"
Uri Alon (2009), "How to choose a good scientific problem" (third reading; this time fill his feasibility/interest chart for Paper 3) (15 min)
In: LABLOOP-W21 Notebook
8/13
Watch
15 min?
W21
Craft
iBiology, "Uri Alon: How to Choose a Good Scientific Problem"
iBiology, "Uri Alon: How to Choose a Good Scientific Problem" (verify; talk version)
In: LABLOOP-W21 Notebook
6/10
Watch
15 min?
W22
Craft
StatQuest "Spearman's Rank Correlation" if needed
StatQuest "Spearman's Rank Correlation" if needed (search; verify) and "Bootstrapping Main Ideas" (carry over)
In: LABLOOP-W22 Notebook
5/9
Watch
15 min
W23
Craft
Khan Academy / Crash Course refresh on protein folding and denaturation ("why heat unfolds prote…
Khan Academy / Crash Course refresh on protein folding and denaturation ("why heat unfolds proteins") (15 min)
In: LABLOOP-W23 Notebook
6/9
Read
30 min?
W24
Craft
LabXchange simulations on protein expression/purification or enzyme assays
LabXchange simulations on protein expression/purification or enzyme assays (search the library; verify availability) so the partner's words land on a picture
In: LABLOOP-W24 Notebook
7/12
Read
30 min?
W25
Craft
Piepho, Büchse & Emrich (2003), "A hitchhiker's guide to mixed models for randomized experiments"
Piepho, Büchse & Emrich (2003), "A hitchhiker's guide to mixed models for randomized experiments", Journal of Agronomy and Crop Science 189:310-322 (skim sections 1-3)
In: LABLOOP-W25 Notebook
7/10
Watch
20 min
W27
Craft
Y Combinator Startup School, "How to Talk to Users"
Y Combinator Startup School, "How to Talk to Users" (Eric Migicovsky, YouTube, ~20 min)
In: LABLOOP-W27 Notebook
3/6
Read
30 min?
W28
Craft
Your own v4 Part 4 pricing hypotheses and Part 3.3 culture filter
In: LABLOOP-W28 Notebook
4/6
Read
30 min?
W28
Craft
AFIP/ARCA guidance on issuing invoices as an independent professional in Argentina
AFIP/ARCA guidance on issuing invoices as an independent professional in Argentina (verify current rules with an accountant; this plan does not give tax advice)
In: LABLOOP-W28 Notebook
3/7
Read
60 min
W29
Craft
The client's papers/patents via P11
The client's papers/patents via P11 (60 min)
In: LABLOOP-W29 Notebook
4/7
Watch
30 min
W29
Craft
Coursera Process Mining: Data Science in Action
Coursera Process Mining: Data Science in Action (Eindhoven), week 1 lecture on event logs (30 min) — cycle time from timestamps is process mining in miniature
In: LABLOOP-W29 Notebook
6/10
Read
20 min
W30
Craft
Weissgerber et al. (2015), "Beyond bar and line graphs: time for a new data presentation paradigm"
Weissgerber et al. (2015), "Beyond bar and line graphs: time for a new data presentation paradigm", PLoS Biology 13(4):e1002128 (20 min)
In: LABLOOP-W30 Notebook
3/5
Read
30 min?
W32
Craft
bioRxiv submission guide
bioRxiv submission guide (carry over); co-author's institution's preprint policy (ask)
In: LABLOOP-W32 Notebook
4/7
Read
20 min
W37
Craft
For pilots: re-read your audit readout and the client's success metric definition
For pilots: re-read your audit readout and the client's success metric definition (20 min)
In: LABLOOP-W37 Notebook
3/6
Watch
60 min
W38
Craft
Patrick Winston, "How to Speak"
Patrick Winston, "How to Speak" (MIT OCW / YouTube, ~1 h; re-watch the first 30 min)
In: LABLOOP-W38 Notebook
4/6
Watch
15 min?
W38
Craft
Simon Peyton Jones, "How to give a great research talk"
Simon Peyton Jones, "How to give a great research talk" (Microsoft Research, YouTube)
In: LABLOOP-W38 Notebook
3/6
Read
30 min?
W39
Craft
v4 Part 4
v4 Part 4 (portfolio package) and Part 9.4 (funds)
In: LABLOOP-W39 Notebook
4/6
Read
30 min?
W39
Craft
Bruce Booth, Life Sci VC
Bruce Booth, Life Sci VC (lifescivc.com) — one post on portfolio support or milestones (search)
In: LABLOOP-W39 Notebook
3/6
Watch
30 min
W40
Craft
Bill Burnett & Dave Evans, Designing Your Life (book, paid) — chapters on "odyssey plans"
Bill Burnett & Dave Evans, Designing Your Life (book, paid) — chapters on "odyssey plans" and "choosing well"; or Bill Burnett's TEDx talk "Designing Your Life" (YouTube, free) (30 min)
In: LABLOOP-W40 Notebook
4/6
Read
30 min
W40
Craft
Richard Hamming, You and Your Research
Richard Hamming, You and Your Research (final re-read; compare your week 0 notes) (30 min)
In: LABLOOP-W40 Notebook