PAPER 3 GATE AND CAREER REFRESH · enzymelens; portfolio; commercial materials

WEEK 32 · Mon 26 Apr → Sun 02 May 2027

Paper 3 gate and career refresh

600 minutes max9 deliverables ◆ Gate: Paper 3enzymelens; portfolio; commercial materials
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UNDERSTAND · PRACTICE · KEEP EVIDENCE

Your full learning notebook

Read the week in plain language, refresh the foundations, follow each challenge step by step, and check what evidence to keep. Includes worked examples, answer keys and prompts for visual study resources.

Use this within your existing weekly blocks. Your learning completion and research evidence remain in your current tracker and week files.

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START HERE · 2 MINUTES

What am I doing right now?

If you only complete one thing:
✓

STATUS

Tracker & deliverables

DeliverableAcceptanceState
paper-3-submission-record.md
Build create +
Resolve author review and verify venue requirements; prepare/submit Paper 3 with truthful contributions and data availability. Acceptance: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.
next-engagement-proposal.md
Build create +
Prepare a second audit or pilot proposal based on measured client needs, with capacity and acceptance criteria. Acceptance: Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit.
career-refresh-pack.md
Build create +
Refresh CV/portfolio/application materials and finalize the case study for publication only with client permission. Acceptance: Three-paper claims match public status; actual application/resubmission actions are logged.
study-notes.md
Learning create +
Selected exact free resources; bounded lesson/exercise; separate solution; quiz and grading rubric; Peter's answers and gaps when executed
founder-paper.md
Founder papers create +
Verified source and P11 digest; authentic question and connection sentence; access limitations
branding-pack.md
Branding create +
Wednesday note, Sunday build log, X adaptation, figure/caption/alt text and the week's special asset; each claim linked to real proof
opportunity-actions.md
Opportunities create +
Qualified target/role, source/date, ladder stage, next action, message/interview/proposal draft and actual status
evidence.md
Evidence & review open & edit ↗
Actual paths/URLs, versions, checks/metrics, preparation versus execution state and external receipts when applicable
review.md
Evidence & review open & edit ↗
Checklist, learning assessment, gate status, shortfalls, next actions and carryover
Notes on artifact states

These filenames are outputs to prepare during this week's execution; this scaffold does not claim they already exist. Drafts and measured results have different states. Technical code/data stay in the canonical project repository and are referenced from these coordinating files.

During preparation, future measured tables get column definitions, input requirements and run instructions with PENDING status. During execution, replace pending values only with measured outputs. Do not create realistic-looking fake evidence.

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600 MINUTES MAXIMUM

Seven-day plan

Monday90 min

Target. Resolve author review and verify venue requirements; prepare/submit Paper 3 with truthful contributions and data availability. Stop when: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.

No material for Monday — this is a pure build day. Need something to study instead? →

Tuesday90 min

Target. No new coursework. Use the block for author review closure and submission metadata. Produce: One concise applied note, a worked decision/example and unresolved questions.

No material for Tuesday — this is a pure build day. Need something to study instead? →

Wednesday90 min

Target. Prepare a second audit or pilot proposal based on measured client needs, with capacity and acceptance criteria. Stop when: Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit. Reserve the last 10 minutes for the optional Wednesday note.

No material for Wednesday — this is a pure build day. Need something to study instead? →

Thursday90 min

Target. Use the block for case-study permission handling and evidence-based application refresh; no additional curriculum. Apply the Half 2 one-formal-study-block rule.

No material for Thursday — this is a pure build day. Need something to study instead? →

Friday90 min

Target. Refresh CV/portfolio/application materials and finalize the case study for publication only with client permission. Stop when: Three-paper claims match public status; actual application/resubmission actions are logged.

No material for Friday — this is a pure build day. Need something to study instead? →

Saturday90 min

Target. Resolve the earliest critical spillover or dependency. Prepare any long-form publication draft from existing figures here if needed. Sandbox only after commitments are met.

Optional, only if the day went well:

  1. Read Andrew Ng, How to Build Your Career in AI Saturday sandbox · 30 min? find ↗
  2. Read Life Sci VC Saturday sandbox · 30 min? · after Andrew Ng, How to Build Your Career in AI find ↗
Sunday60 min

Target. 20 min build-log draft/publication when authorized; 5 min evidence/checklist; 20 min source-grounded gap review; 15 min next week's six physical actions.

No material for Sunday — this is a pure build day. Need something to study instead? →

Any time this week3 cards, 90 min · the plan names no day for these

Spare pockets, repo exercises and anything the plan lists without a day. Take them in this order when a day finishes early.

  1. Read bioRxiv submission guide 30 min? find ↗
  2. Run Zenodo + GitHub (yours) 30 min find ↗
  3. Run marimo-team/marimo 30 min open ↗
Block ritual: read your next action → start the 90-min timer → open one file. Close: write tomorrow's action and one log line.
Feels pointless? Does today's Done when need it? No → skip it and log it. Yes → let AI do the boring part, you review. Still stuck → the smallest version in 25 minutes. Pulled into a rabbit hole? Write it in Parked thoughts and save it for Saturday.

The model must turn these into exact physical actions using the observed files and available inputs. Each 90-minute block includes start/stop rituals. All calls, posts, debugging, reading and exercises consume this same capacity.

Half 2: Tuesday is the formal study block unless this is a selling/submission/decision week. Thursday supports applied review, partner work or the market task; do not add another full course.

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WHAT TO WATCH, READ AND RUN

Materials for this week

The local guide signs the map. Paper 3 goes to bioRxiv with your co-author's name next to yours, and the case study goes public with your client's permission. These two artifacts together say something no certificate can: scientists trust my method, and companies pay for it. You also send a second audit or pilot proposal, because the best time to sell the second engagement is the week the first one becomes a story. …

0 of 5 finished · give me one to start now → · open in the deck →

In the plan's running order: each card says which block it belongs to and what has to come before it. The seven-day plan lists the same cards under the day that owns them.

Saturday · sandbox, optional 2 · 60 min total

1/5 Read 30 min? W32 Saturday Sandbox optional

Andrew Ng, How to Build Your Career in AI

Saturday sandbox

Andrew Ng, How to Build Your Career in AI (free eBook from DeepLearning.AI; verify availability) — chapters on job search and portfolio

Find it ↗ search

In: LABLOOP-W32 Notebook

2/5 Read 30 min? W32 Saturday Sandbox optional

Life Sci VC

Saturday sandbox · after Andrew Ng, How to Build Your Career in AI

Life Sci VC (Bruce Booth) posts on how biotech boards evaluate consultants and fractional executives (search)

Find it ↗ search

In: LABLOOP-W32 Notebook

Any block this week — the plan names no day 3 · 90 min total

3/5 Read 30 min? W32 Craft

bioRxiv submission guide

bioRxiv submission guide (carry over); co-author's institution's preprint policy (ask)

Find it ↗ search

In: LABLOOP-W32 Notebook

4/5 Run 30 min W32 Build

Zenodo + GitHub (yours)

Release enzymelens v1.0 with DOI; link from the preprint

Find it ↗ search

In: LABLOOP-W32 Notebook

5/5 Run 30 min W32 Build

marimo-team/marimo

Interactive "candidate explorer" for the paper's supplementary material (public data only)

Open ↗

In: LABLOOP-W32 Notebook

01

READ FIRST

Outcome and relevance

This week delivers the three concrete artifacts below and the supporting learning/branding/opportunity pack. The scientific or commercial outcome follows the preserved source brief, while the acceptance checks make its evidence testable. The career objective is to turn this work into something a scientist, hiring manager or buyer can inspect.

  • Scientific/build priority: Resolve author review and verify venue requirements; prepare/submit Paper 3 with truthful contributions and data availability.
  • Public/profile priority: Prepare X3 launch assets and a consented case-study version; update scientific bio and featured links.
  • Career/relationship/commercial priority: Revisit the verified employer shortlist and recruiter contacts with new evidence; track employment and client funnels separately.
02

READ FIRST

Deeper walkthrough (v6)

Read v6 · Week 32 · GATE 32: Paper 3 preprint (L4 co-authored) before Monday. It expands this week's one-row v5 brief into daily build steps and adds the Welcome analogy, Learn it (▶ core and + deeper sources), Run it (repos with a 20-40 minute exercise), the NotebookLM kit and the mentor check below. Standing v6 rules: resource rules, NotebookLM protocol, chapter anatomy. v6 adds depth only; it does not change a goal, gate, output or the 600-minute cap, so this specification still governs execution.

Act VI (finale) · Threads: EL, $, R · GATE 32

Where this week sits. - ← From: Acts V and VI. - → Feeds: week 36 (journal decisions), week 37 (pilot or job), week 38 (talk), week 39 (fund package), week 40 (decision). - ⟳ Returns in: every introduction from now on: "co-author with [lab]".

Goals. - 🎯 This week: Paper 3 on bioRxiv with co-author; case study published with permission; second audit or pilot proposal sent; career assets refreshed. - 🏁 This gate (32): L4 co-authored. - 🌟 Final: L5 reviewed and invited (weeks 36-40).

The plan (from v5 Part 7, expanded; gate and output unchanged).

v5 row: 32 | GATE 32: Paper 3 preprint (L4 co-authored) | none | bioRxiv submission with co-author; second audit or pilot proposal sent | X3. Case study published with client permission - Goal: X3 exists and the practice has a second opportunity in motion. - Build: Mon: final co-author sign-off; bioRxiv submission; code/data DOIs. Wed: case study published (LinkedIn article + site); second audit or pilot proposal sent to the week 29 client or the best week 27 prospect. Fri: headline and site updated; 5 new applications or fractional-role conversations with three preprints (Part 9.4). - Sun: L-Sun: the preprint, credited to both authors. X3. Gauge: L4 (co-authored). - Gate 32 passes when: bioRxiv DOI with co-author exists. - Only one thing: the submission.

Mentor check. "I am a co-author with a scientist and a paid consultant with a public case study."

03

OPEN WHEN NEEDED

Required inputs and dependency check

04

READ FIRST

Learning specification

Biology/domain unit

Material: No new coursework. Use the block for author review closure and submission metadata.

Produce: One concise applied note, a worked decision/example and unresolved questions.

Understanding check: The note directly supports this week's experiment, collaboration, delivery or career action.

During preparation, write one worked example connected to the week's actual task, one exercise with a separate answer key and five questions. Peter supplies answers; score explanation quality and flag misconceptions in QUESTIONS. Numeric/scientific conclusions require actual data or explicitly synthetic teaching values.

AI/scientific-method unit

Material: Use the block for case-study permission handling and evidence-based application refresh; no additional curriculum.

Produce: One concise applied note, a worked decision/example and unresolved questions.

Understanding check: The note directly supports this week's experiment, collaboration, delivery or career action.

Use the prompt pack: P1 explanation ladder, P2 concept-to-project bridge and P3 quiz. Coding practice belongs within the allocated study/build block. Where the source asks for a favorable scientific result, substitute an honest measured comparison as explained below.

Founder/scientist paper

Select one verified founder/scientific-lead paper relevant to this week's domain. Use P11; save the question, method, numerical result with context, data workflow, three author questions and one connection sentence in founder-paper.md. Keep abstract-only access limitations explicit. On source weeks with no study, prioritize the commercial/submission task and log any skipped digest.

05

OPEN WHEN NEEDED

Branding and opportunity execution brief

Branding: Prepare X3 launch assets and a consented case-study version; update scientific bio and featured links.

Opportunity action: Revisit the verified employer shortlist and recruiter contacts with new evidence; track employment and client funnels separately.

Use career asset contracts. Publish at most the agreed cadence; one figure and one supported number or admitted failure can support multiple drafts. In long-form weeks, prepare a 1,500–2,500-word article from existing evidence within the build/buffer allocation. In release/demo weeks, prepare a 60-second script: problem, input, command/action, result, limitation and proof link.

Verify individuals, jobs and affiliations at execution time. The GridX list and v4 company map are research seeds, not current facts. Do not reveal named company weaknesses or employer/client confidential information. Keep drafted/sent/replied/booked/held statuses separate. The planning request alone does not authorize external messages or publication; honor explicit authorization in the execution session.

06

OPEN WHEN NEEDED

Quality risks and week-specific constraints

A computational-only or pending submission cannot be marked as the source co-authored public-preprint gate. Record shortfalls while progressing the allowed alternative.

Apply the root scientific evidence contract: provenance; meaningful independent splits; no future-data leakage; baseline comparison; actual denominators/uncertainty; failed cases; human review where required. State whether data are simulated, public experimental, synthetic or partner-provided.

Keep source gates intact, and log scope/time conflicts in review. Missing people, money, access or results must not be replaced with invented evidence. Reduce optional polish first. A specific essential external dependency stays pending while independent preparation continues.

07

READ FIRST

Completion and gate review

This is Gate 32: Paper 3.

Required proof: Public preprint DOI with a contributing scientist as co-author and all authors' approval.

Reputation interpretation: L4-co-authored when public. Record target, forecast, actual date and evidence link. The original gate stays incomplete until the required external proof exists.

  • Monday artifact satisfies: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.
  • Wednesday artifact satisfies: Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit.
  • Friday artifact satisfies: Three-paper claims match public status; actual application/resubmission actions are logged.
  • Study pack is prepared; Peter's actual learning/quiz result is recorded separately.
  • Branding and opportunity drafts use supported claims and the correct external-action state.
  • Reproduction or document checks are recorded with file/version references.
  • This week's special gate, if any, has real evidence or remains explicitly pending.
  • Review, root progress/log and the next physical action are updated.
08

READ FIRST

Minimum viable week and recovery

Expanded minimum derived from the source goal: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.

Operational first step if stalled: open paper-3-submission-record.md, write the required inputs and produce the smallest checkable example in ten minutes. If a more urgent missing gate dependency controls the week, use the source minimum above.

If the full week does not fit, use P14: retain one gate-critical deliverable and one directly supporting study exercise; record what is skipped versus moved. Do not mark the original full gate passed merely because the minimum was completed. After a missed week, reforecast from actual evidence and avoid a second unexamined lost week.

09

OPEN WHEN NEEDED

Handoff to the next model

In review, state exactly what exists, what was verified, what Peter can now explain, which external events remain pending, where the canonical code/data live, and the next file/function or draft paragraph to touch. Link each fact to evidence. Carry scientific assumptions, split definitions and rights constraints forward explicitly.

10

OPEN WHEN NEEDED

Ready-to-copy model prompt

Prepare Week 32 of this LABLOOP execution plan.
Read execution-plan/specs.md, execution-plan/DECISIONS.md,
execution-plan/GATES.md and
execution-plan/weeks/week-32-paper-3-gate-and-career-refresh/specs.md, commitment.md, evidence.md and review.md.
Read prior prerequisite reviews and inspect actual repository/data state.
Use v5 as the governing sequence, the v6 Week 32 chapter
(LABLOOP-Master-Plan-v6.md) as the deeper walkthrough, and v4 only for
retained details.
Produce the full local preparation pack and the exact week-specific files named
in the artifact table. Give me a bounded lesson with exercises/answer key,
daily physical actions, technical runbook or draft, branding drafts and
career/commercial actions. Keep the total to 600 minutes.
Separate prepared artifacts from measured results and my learning completion.
Verify sources and do not invent metrics, citations, papers, people or outcomes.
Do not execute external communications, publication or spending unless the
current session already authorizes the specific action.
Finish by updating evidence/review and TODAY with the next physical action.
11

OPEN WHEN NEEDED

Preserved original v5 weekly brief

v6 expands this row into a full brief, with the gate and output unchanged, inside v6 · Week 32 · GATE 32: Paper 3 preprint (L4 co-authored). The following is source planning text, not a claim of completion. Apply the explicit evidence corrections in this specification and DECISIONS.md.

Week Goal Study (Tue) Build (Mon/Wed/Fri) Output
32 GATE 32: Paper 3 preprint (L4 co-authored) none bioRxiv submission with co-author; second audit or pilot proposal sent X3. Case study published with client permission
📄

WEEK FILES

Commitment · evidence · review

commitment.md open ↗

State: UNCONFIRMED. Owner: Peter Ciancaglini. Specification

Start date: not set. End date: not set. Available hours: confirm (planned ceiling 10). Primary outcome: paper 3 gate and career refresh. Minimum that keeps the next gate alive: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.

Deliverables to commit

  • ☐ paper-3-submission-record.md: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists.
  • ☐ next-engagement-proposal.md: Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit.
  • ☐ career-refresh-pack.md: Three-paper claims match public status; actual application/resubmission actions are logged.
  • ☐ Bounded learning exercise and personal teach-back.
  • ☐ Evidence-backed branding and opportunity pack.
  • ☐ Sunday review and next physical action.

Proposed calendar

Day Minutes Physical action / outcome Actual slot Done
Mon 90 Resolve author review and verify venue requirements; prepare/submit Paper 3 with truthful contributions and data availability. Not set ☐
Tue 90 One concise applied note, a worked decision/example and unresolved questions. Not set ☐
Wed 90 Prepare a second audit or pilot proposal based on measured client needs, with capacity and acceptance criteria. Last ten minutes: optional note. Not set ☐
Thu 90 One concise applied note, a worked decision/example and unresolved questions. Include relevant founder-paper work within this block. Not set ☐
Fri 90 Refresh CV/portfolio/application materials and finalize the case study for publication only with client permission. Not set ☐
Sat 90 Resolve critical spillover; long-form draft if due; sandbox only if done. Not set ☐
Sun 60 Build log, evidence, gap review, next actions. Not set ☐

Dependency and capacity check

  • Missing essential inputs: not yet inspected.
  • Human/external dependency, owner and expected date: not yet inspected.
  • Week-specific constraint: A computational-only or pending submission cannot be marked as the source co-authored public-preprint gate. Record shortfalls while progressing the allowed alternative.
  • Existing session authorization for external actions or spending: not assessed; local planning only at scaffold creation.
  • Scope to cut first: optional polish/additional examples; preserve scientific validity.
  • If the forecast exceeds available time: record a concrete reduced scope or revised delivery proposal before committing.

Peter's commitment / adjustments: pending. Reviewing model and date: pending.

evidence.md open ↗

Execution state: NOT_STARTED. Specification This file is a blank register with planned artifact names; none of the rows prove completion.

Item Path / URL / version State Verification / actual result Verified by / date
paper-3-submission-record.md Not created NOT_STARTED Pending: All listed authors approve; receipt/public DOI and co-authored status are separate. —
next-engagement-proposal.md Not created NOT_STARTED Pending: Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit. —
career-refresh-pack.md Not created NOT_STARTED Pending: Three-paper claims match public status; actual application/resubmission actions are logged. —
Learning exercise / Peter's quiz Not created NOT_STARTED Peter's actual answers required —
Founder paper digest Not created NOT_STARTED Source/content and access checked —
Branding pack Not created NOT_STARTED Claims audited; drafted/public status distinct —
Opportunity actions Not created NOT_STARTED Drafted/sent/replied/booked/held distinct —
Gate 32 No evidence NOT_STARTED Public preprint DOI with a contributing scientist as co-author and all authors' approval. —

Reproduction and scientific measurements

Question / metric Dataset, N and unit Split / seed / config Command or verification method Output path and measured value Uncertainty / limitation

External events, when authorized and actually performed

Date Action / counterpart Receipt or private reference State Next action / date

Actual learning and decisions

Peter's teach-back / quiz score: not assessed. Scientific assumptions and deviations: none recorded yet. Budget allocated / spent: not assessed / no spend recorded. Missing evidence and responsible owner: pending inspection.

Do not put API keys, source full texts with restricted rights, client data or invoice personal details in a public version of this register. Keep private evidence references private.

review.md open ↗

Review status: NOT_REVIEWED. Specification · Evidence

What was actually completed?

  • ☐ Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists. Evidence: pending.
  • ☐ Evidence, buyer, scope, fee hypothesis, timeline and next decision are explicit. Evidence: pending.
  • ☐ Three-paper claims match public status; actual application/resubmission actions are logged. Evidence: pending.
  • ☐ Learning assessed from Peter's actual answers. Evidence: pending.
  • ☐ Branding/opportunity states recorded correctly. Evidence: pending.

Learning and outcome

What Peter can explain or reproduce now: not assessed. Quiz / teach-back gaps: not assessed. Measured result and limitations: pending. Best evidence link for a scientist/recruiter/buyer: pending. What failed or changed, and why: pending.

Gate and capacity

Gate requirement: Public preprint DOI with a contributing scientist as co-author and all authors' approval. Gate status: NOT_STARTED. Original target week: 32. Actual completion date / forecast: not set. Missing external evidence: pending inspection. Blocks completed / 7: not recorded. Days with commits / 7: not recorded. Sunday build log / optional Wednesday note: not recorded. Founder conversations cumulative: not recorded. Earned evidence level and proof: not assessed. Consecutive lost weeks: not assessed.

Week-specific risk to revisit: A computational-only or pending submission cannot be marked as the source co-authored public-preprint gate. Record shortfalls while progressing the allowed alternative.

Decision and next-model handoff

Continue / recover / blocked: not decided. Retain as the minimum: Complete an author-approved Paper 3 submission package and submit when authorized; keep public/co-authored gate status pending until its evidence exists. Skipped permanently with reason: none recorded. Carryover with owner, dependency and target week: none recorded. Canonical repository paths and versions: pending. Data permissions, split definitions or assumptions to preserve: pending. External action authorization that still applies: not assessed. Next physical action, exact file/function/paragraph: pending. Updates to root PROGRESS / LOG / TODAY completed: ☐

Next week

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YOUR SPACE

Notes, links & media

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    ⏱ Focus Focus25:00 0 min today