WEEK 10 · Mon 23 Nov → Sun 29 Nov 2026

Annotation agreement and analysis

600 minutes max9 deliverables fermlit
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UNDERSTAND · PRACTICE · KEEP EVIDENCE

Your full learning notebook

Read the week in plain language, refresh the foundations, follow each challenge step by step, and check what evidence to keep. Includes worked examples, answer keys and prompts for visual study resources.

Use this within your existing weekly blocks. Your learning completion and research evidence remain in your current tracker and week files.

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START HERE · 2 MINUTES

What am I doing right now?

If you only complete one thing: kappa.
✓

STATUS

Tracker & deliverables

DeliverableAcceptanceState
agreement-report.md
Build create +
Receive the second human's independent 30-paper annotations, calculate categorical agreement/kappa and numeric tolerance agreement, then adjudicate. Acceptance: Pre-adjudication labels are retained and agreement is reported by field and support.
descriptive-analysis.md
Build create +
Analyze titer/product/organism, scale and reporting patterns with denominators and comparable units. Acceptance: Exploratory comparisons are labeled; no causal or cross-product efficacy claims.
figure-inventory.md
Build create +
Generate Paper 1 figures 1–4 with frozen data/version and export static versions plus captions. Acceptance: One command regenerates each plot and caption N agrees with the table.
study-notes.md
Learning create +
Selected exact free resources; bounded lesson/exercise; separate solution; quiz and grading rubric; Peter's answers and gaps when executed
founder-paper.md
Founder papers create +
Verified source and P11 digest; authentic question and connection sentence; access limitations
branding-pack.md
Branding create +
Wednesday note, Sunday build log, X adaptation, figure/caption/alt text and the week's special asset; each claim linked to real proof
opportunity-actions.md
Opportunities create +
Qualified target/role, source/date, ladder stage, next action, message/interview/proposal draft and actual status
evidence.md
Evidence & review open & edit ↗
Actual paths/URLs, versions, checks/metrics, preparation versus execution state and external receipts when applicable
review.md
Evidence & review open & edit ↗
Checklist, learning assessment, gate status, shortfalls, next actions and carryover
Notes on artifact states

These filenames are outputs to prepare during this week's execution; this scaffold does not claim they already exist. Drafts and measured results have different states. Technical code/data stay in the canonical project repository and are referenced from these coordinating files.

During preparation, future measured tables get column definitions, input requirements and run instructions with PENDING status. During execution, replace pending values only with measured outputs. Do not create realistic-looking fake evidence.

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600 MINUTES MAXIMUM

Seven-day plan

Monday90 min· 1 card, 30 min

Target. Receive the second human's independent 30-paper annotations, calculate categorical agreement/kappa and numeric tolerance agreement, then adjudicate. Stop when: Pre-adjudication labels are retained and agreement is reported by field and support.

Do these in this order — the plan's own sequence:

  1. Read McHugh 30 min? · Read it inside Monday's build block find ↗
Tuesday90 min· 1 card, 75 min

Target. NPTEL lectures 4-6 (Monod, yields, maintenance) Produce: Yield coefficients computed on IndPenSim

Do these in this order — the plan's own sequence:

  1. Watch NPTEL Bioreactors 75 min find ↗
Wednesday90 min

Target. Analyze titer/product/organism, scale and reporting patterns with denominators and comparable units. Stop when: Exploratory comparisons are labeled; no causal or cross-product efficacy claims. Reserve the last 10 minutes for the optional Wednesday note.

No material for Wednesday — this is a pure build day. Need something to study instead? →

Thursday90 min· 1 card, 45 min

Target. Rasmussen & Williams, *GPML* ch. 1-2 — gaussianprocess.org/gpml (free); scikit-learn GP examples Select material/exercise that fits 60 minutes; use the last 30 for the founder paper.

Do these in this order — the plan's own sequence:

  1. Read Rasmussen & Williams, Gaussian Processes for Machine Learning, ch. 1-2 — gaussianprocess.org/gpm… 45 min open ↗
Friday90 min

Target. Generate Paper 1 figures 1–4 with frozen data/version and export static versions plus captions. Stop when: One command regenerates each plot and caption N agrees with the table.

No material for Friday — this is a pure build day. Need something to study instead? →

Saturday90 min

Target. Resolve the earliest critical spillover or dependency. Prepare any long-form publication draft from existing figures here if needed. Sandbox only after commitments are met.

Optional, only if the day went well:

  1. Watch ritvikmath "Gaussian Processes" Saturday sandbox · 15 min? find ↗
  2. Watch StatQuest "Confidence Intervals, Clearly Explained" and "The Standard Error" Saturday sandbox · 15 min? · after ritvikmath "Gaussian Processes" find ↗
  3. Read Krippendorff's alpha Saturday sandbox · 30 min? · after StatQuest "Confidence Intervals, Clearly Explained" and "The Standard Error" find ↗
  4. Read Modern Statistics for Modern Biology (Holmes & Huber) ch. 3 "High quality graphics in R" Saturday sandbox · 30 min? · after Krippendorff's alpha find ↗
Sunday60 min

Target. 20 min build-log draft/publication when authorized; 5 min evidence/checklist; 20 min source-grounded gap review; 15 min next week's six physical actions.

No material for Sunday — this is a pure build day. Need something to study instead? →

Any time this week4 cards, 120 min · the plan names no day for these

Spare pockets, repo exercises and anything the plan lists without a day. Take them in this order when a day finishes early.

  1. Run scikit-learn/scikit-learn 30 min open ↗
  2. Run cornellius-gp/gpytorch 30 min open ↗
  3. Run pln-fing-udelar/fast-krippendorff 30 min open ↗
  4. Run plotly/plotly.py / mwaskom/seaborn 30 min find ↗
Block ritual: read your next action → start the 90-min timer → open one file. Close: write tomorrow's action and one log line.
Feels pointless? Does today's Done when need it? No → skip it and log it. Yes → let AI do the boring part, you review. Still stuck → the smallest version in 25 minutes. Pulled into a rabbit hole? Write it in Parked thoughts and save it for Saturday.

The model must turn these into exact physical actions using the observed files and available inputs. Each 90-minute block includes start/stop rituals. All calls, posts, debugging, reading and exercises consume this same capacity.

The source lists more material than necessarily fits. Select exact excerpts for the learning objective and park the remainder; no full-course completion requirement.

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WHAT TO WATCH, READ AND RUN

Materials for this week

Two referees watching the same match will not call every foul the same way. If they disagree constantly, the rules are unclear, not the players. Cohen's kappa measures how much two annotators agree beyond what chance alone would give, and it is the number that tells reviewers whether your gold set is a standard or an opinion. This week you compute it per field, sit down with the disagreements, adjudicate them, and f…

0 of 11 finished · give me one to start now → · open in the deck →

In the plan's running order: each card says which block it belongs to and what has to come before it. The seven-day plan lists the same cards under the day that owns them.

Monday 1 · 30 min total

1/11 Read 30 min? W10 Monday Craft

McHugh

Monday build block · Read it inside Monday's build block

Build-block reading · McHugh (2012) kappa paper (carry over from week 6), results interpretation table

Find it ↗ search

In: LABLOOP-W10 Notebook

Tuesday 1 · 75 min total

2/11 Watch 75 min W10 Tuesday Biology

NPTEL Bioreactors

NPTEL Bioreactors lectures 4-6 (Monod, yields, maintenance) (75 min)

Find it ↗ search

In: LABLOOP-W10 Notebook

Thursday 1 · 45 min total

3/11 Read 45 min W10 Thursday AI & stats

Rasmussen & Williams, Gaussian Processes for Machine Learning, ch. 1-2 — gaussianprocess.org/gpm…

Rasmussen & Williams, Gaussian Processes for Machine Learning, ch. 1-2 — gaussianprocess.org/gpml (free) (45 min) after Görtler, Kehlbeck & Deussen (2019), "A Visual Exploration of Gaussian Processes", Distill — distill.pub/2019/visual-exploration-gaussian-processes (30 min, interactive; start here)

Open ↗

In: LABLOOP-W10 Notebook

Saturday · sandbox, optional 4 · 90 min total

4/11 Watch 15 min? W10 Saturday Sandbox optional

ritvikmath "Gaussian Processes"

Saturday sandbox

ritvikmath "Gaussian Processes" (YouTube, whiteboard intuition)

Find it ↗ search

In: LABLOOP-W10 Notebook

5/11 Watch 15 min? W10 Saturday Sandbox optional

StatQuest "Confidence Intervals, Clearly Explained" and "The Standard Error"

Saturday sandbox · after ritvikmath "Gaussian Processes"

Find it ↗ search

In: LABLOOP-W10 Notebook

6/11 Read 30 min? W10 Saturday Sandbox optional

Krippendorff's alpha

Saturday sandbox · after StatQuest "Confidence Intervals, Clearly Explained" and "The Standard Error"

Krippendorff's alpha (Wikipedia page is good) for when you have more than two annotators or missing ratings

Find it ↗ search

In: LABLOOP-W10 Notebook

7/11 Read 30 min? W10 Saturday Sandbox optional

Modern Statistics for Modern Biology (Holmes & Huber) ch. 3 "High quality graphics in R"

Saturday sandbox · after Krippendorff's alpha

Modern Statistics for Modern Biology (Holmes & Huber) ch. 3 "High quality graphics in R" — read for the design principles, ignore the R

Find it ↗ search

In: LABLOOP-W10 Notebook

Any block this week — the plan names no day 4 · 120 min total

8/11 Run 30 min W10 Build

scikit-learn/scikit-learn

sklearn.metrics.cohen_kappa_score per field; gallery example "Gaussian process regression: basic introductory example"

Open ↗

In: LABLOOP-W10 Notebook

9/11 Run 30 min W10 Build

cornellius-gp/gpytorch

"Simple GP Regression" tutorial notebook in Colab; add predictive variance bands to one soft-sensor feature

Open ↗

In: LABLOOP-W10 Notebook

10/11 Run 30 min W10 Build

pln-fing-udelar/fast-krippendorff

Compute alpha on the same annotations; compare with kappa and write one sentence on why they differ

Open ↗

In: LABLOOP-W10 Notebook

11/11 Run 30 min W10 Build

plotly/plotly.py / mwaskom/seaborn

Build figure 1 (completeness by field) as a static, publication-ready image

Find it ↗ search

In: LABLOOP-W10 Notebook

01

READ FIRST

Outcome and relevance

This week delivers the three concrete artifacts below and the supporting learning/branding/opportunity pack. The scientific or commercial outcome follows the preserved source brief, while the acceptance checks make its evidence testable. The career objective is to turn this work into something a scientist, hiring manager or buyer can inspect.

  • Scientific/build priority: Receive the second human's independent 30-paper annotations, calculate categorical agreement/kappa and numeric tolerance agreement, then adjudicate.
  • Public/profile priority: Prepare a two-human agreement explanation; publish actual overlap and metrics only after labels arrive.
  • Career/relationship/commercial priority: Give the annotator credit appropriate to contribution; prepare a follow-up scientific-feedback message using one figure.
02

READ FIRST

Deeper walkthrough (v6)

Read v6 · Week 10 · Inter-annotator agreement and the first real analysis before Monday. It carries this week's v5 brief unchanged and adds the Welcome analogy, Learn it (▶ core and + deeper sources), Run it (repos with a 20-40 minute exercise), the NotebookLM kit and the mentor check below. Standing v6 rules: resource rules, NotebookLM protocol, chapter anatomy. v6 adds depth only; it does not change a goal, gate, output or the 600-minute cap, so this specification still governs execution.

Act III · Threads: B, M, FL · Next gate: 13

Where this week sits. - ← From: week 6 gold set + second annotator; week 9 2,000 records. - → Feeds: week 11 (formal completeness result), week 13 (Paper 1 skeleton figures), week 14 (Methods), week 16 (conformal prediction extends the GP's uncertainty idea), week 34 (judge-human agreement in labdocs). - ⟳ Returns in: Paper 1 "Annotation agreement" paragraph and figures 1-4.

Goals. - 🎯 This week: kappa per field in eval/README.md; gold v1 frozen; descriptive notebook; make figs regenerates figures 1-4. - 🏁 Next milestone: Gate 13. - 🌟 Final: the trust number in Paper 1's abstract.

Mentor check. "I can explain kappa to a founder with a referee analogy and tell them which FermLit fields are trustworthy."

03

OPEN WHEN NEEDED

Required inputs and dependency check

04

READ FIRST

Learning specification

Biology/domain unit

Source unit: B10 · Bioreactors II: kinetics and yields

Material: NPTEL lectures 4-6 (Monod, yields, maintenance)

Produce: Yield coefficients computed on IndPenSim

Understanding check: You can explain Yx/s and Yp/x

During preparation, write one worked example connected to the week's actual task, one exercise with a separate answer key and five questions. Peter supplies answers; score explanation quality and flag misconceptions in QUESTIONS. Numeric/scientific conclusions require actual data or explicitly synthetic teaching values.

AI/scientific-method unit

Source unit: M10 · Gaussian processes

Material: Rasmussen & Williams, GPML ch. 1-2 — gaussianprocess.org/gpml (free); scikit-learn GP examples

Produce: GP soft sensor with uncertainty bands

Understanding check: You can explain a kernel as "similarity"

Use the prompt pack: P1 explanation ladder, P2 concept-to-project bridge and P3 quiz. Coding practice belongs within the allocated study/build block. Where the source asks for a favorable scientific result, substitute an honest measured comparison as explained below.

Founder/scientist paper

Select one verified founder/scientific-lead paper relevant to this week's domain. Use P11; save the question, method, numerical result with context, data workflow, three author questions and one connection sentence in founder-paper.md. Keep abstract-only access limitations explicit. On source weeks with no study, prioritize the commercial/submission task and log any skipped digest.

05

OPEN WHEN NEEDED

Branding and opportunity execution brief

Branding: Prepare a two-human agreement explanation; publish actual overlap and metrics only after labels arrive.

Opportunity action: Give the annotator credit appropriate to contribution; prepare a follow-up scientific-feedback message using one figure.

Use career asset contracts. Publish at most the agreed cadence; one figure and one supported number or admitted failure can support multiple drafts. In long-form weeks, prepare a 1,500–2,500-word article from existing evidence within the build/buffer allocation. In release/demo weeks, prepare a 60-second script: problem, input, command/action, result, limitation and proof link.

Verify individuals, jobs and affiliations at execution time. The GridX list and v4 company map are research seeds, not current facts. Do not reveal named company weaknesses or employer/client confidential information. Keep drafted/sent/replied/booked/held statuses separate. The planning request alone does not authorize external messages or publication; honor explicit authorization in the execution session.

06

OPEN WHEN NEEDED

Quality risks and week-specific constraints

Kappa is not an agreement statistic for continuous raw measurements without justified categorization. If the second annotator is delayed, agreement stays pending and downstream release limitations must be explicit.

Apply the root scientific evidence contract: provenance; meaningful independent splits; no future-data leakage; baseline comparison; actual denominators/uncertainty; failed cases; human review where required. State whether data are simulated, public experimental, synthetic or partner-provided.

Keep source gates intact, and log scope/time conflicts in review. Missing people, money, access or results must not be replaced with invented evidence. Reduce optional polish first. A specific essential external dependency stays pending while independent preparation continues.

07

READ FIRST

Completion and gate review

This is an enabling week. Its deliverables feed the next scheduled gate: 13. Complete the acceptance checklist below; do not promote reputation from a draft.

  • Monday artifact satisfies: Pre-adjudication labels are retained and agreement is reported by field and support.
  • Wednesday artifact satisfies: Exploratory comparisons are labeled; no causal or cross-product efficacy claims.
  • Friday artifact satisfies: One command regenerates each plot and caption N agrees with the table.
  • Study pack is prepared; Peter's actual learning/quiz result is recorded separately.
  • Branding and opportunity drafts use supported claims and the correct external-action state.
  • Reproduction or document checks are recorded with file/version references.
  • This week's special gate, if any, has real evidence or remains explicitly pending.
  • Review, root progress/log and the next physical action are updated.
08

READ FIRST

Minimum viable week and recovery

Source-preserving minimum: kappa.

Operational first step if stalled: open agreement-report.md, write the required inputs and produce the smallest checkable example in ten minutes. If a more urgent missing gate dependency controls the week, use the source minimum above.

If the full week does not fit, use P14: retain one gate-critical deliverable and one directly supporting study exercise; record what is skipped versus moved. Do not mark the original full gate passed merely because the minimum was completed. After a missed week, reforecast from actual evidence and avoid a second unexamined lost week.

09

OPEN WHEN NEEDED

Handoff to the next model

In review, state exactly what exists, what was verified, what Peter can now explain, which external events remain pending, where the canonical code/data live, and the next file/function or draft paragraph to touch. Link each fact to evidence. Carry scientific assumptions, split definitions and rights constraints forward explicitly.

10

OPEN WHEN NEEDED

Ready-to-copy model prompt

Prepare Week 10 of this LABLOOP execution plan.
Read execution-plan/specs.md, execution-plan/DECISIONS.md,
execution-plan/GATES.md and
execution-plan/weeks/week-10-annotation-agreement-and-analysis/specs.md, commitment.md, evidence.md and review.md.
Read prior prerequisite reviews and inspect actual repository/data state.
Use v5 as the governing sequence, the v6 Week 10 chapter
(LABLOOP-Master-Plan-v6.md) as the deeper walkthrough, and v4 only for
retained details.
Produce the full local preparation pack and the exact week-specific files named
in the artifact table. Give me a bounded lesson with exercises/answer key,
daily physical actions, technical runbook or draft, branding drafts and
career/commercial actions. Keep the total to 600 minutes.
Separate prepared artifacts from measured results and my learning completion.
Verify sources and do not invent metrics, citations, papers, people or outcomes.
Do not execute external communications, publication or spending unless the
current session already authorizes the specific action.
Finish by updating evidence/review and TODAY with the next physical action.
11

OPEN WHEN NEEDED

Preserved original v5 weekly brief

v6 reproduces this brief unchanged inside v6 · Week 10 · Inter-annotator agreement and the first real analysis. The following is source planning text, not a claim of completion. Apply the explicit evidence corrections in this specification and DECISIONS.md.

Week 10 · Inter-annotator agreement and the first real analysis

  • Goal: kappa reported; first descriptive science.
  • Tue (B10): NPTEL 4-6; yields on IndPenSim.
  • Thu (M10): GPML ch. 1-2; GP soft sensor with bands.
  • Build: Mon: compute Cohen's kappa per field between you and the second annotator; adjudicate disagreements; freeze gold v1. Done when kappa is in eval/README.md. Wed: descriptive analysis notebook: titer by organism and product, productivity vs scale, reporting completeness by year and journal. Fri: figures 1-4 of Paper 1 drafted (Plotly to static). Done when make figs regenerates them.
  • Sun: L-Sun: "Two humans, 30 papers, kappa = X: how much can you trust a dataset built by an LLM?" L-Wed.
  • Only one thing: kappa.
📄

WEEK FILES

Commitment · evidence · review

commitment.md open ↗

State: UNCONFIRMED. Owner: Peter Ciancaglini. Specification

Start date: not set. End date: not set. Available hours: confirm (planned ceiling 10). Primary outcome: annotation agreement and analysis. Minimum that keeps the next gate alive: kappa.

Deliverables to commit

  • ☐ agreement-report.md: Pre-adjudication labels are retained and agreement is reported by field and support.
  • ☐ descriptive-analysis.md: Exploratory comparisons are labeled; no causal or cross-product efficacy claims.
  • ☐ figure-inventory.md: One command regenerates each plot and caption N agrees with the table.
  • ☐ Bounded learning exercise and personal teach-back.
  • ☐ Evidence-backed branding and opportunity pack.
  • ☐ Sunday review and next physical action.

Proposed calendar

Day Minutes Physical action / outcome Actual slot Done
Mon 90 Receive the second human's independent 30-paper annotations, calculate categorical agreement/kappa and numeric tolerance agreement, then adjudicate. Not set ☐
Tue 90 Yield coefficients computed on IndPenSim Not set ☐
Wed 90 Analyze titer/product/organism, scale and reporting patterns with denominators and comparable units. Last ten minutes: optional note. Not set ☐
Thu 90 GP soft sensor with uncertainty bands Include relevant founder-paper work within this block. Not set ☐
Fri 90 Generate Paper 1 figures 1–4 with frozen data/version and export static versions plus captions. Not set ☐
Sat 90 Resolve critical spillover; long-form draft if due; sandbox only if done. Not set ☐
Sun 60 Build log, evidence, gap review, next actions. Not set ☐

Dependency and capacity check

  • Missing essential inputs: not yet inspected.
  • Human/external dependency, owner and expected date: not yet inspected.
  • Week-specific constraint: Kappa is not an agreement statistic for continuous raw measurements without justified categorization. If the second annotator is delayed, agreement stays pending and downstream release limitations must be explicit.
  • Existing session authorization for external actions or spending: not assessed; local planning only at scaffold creation.
  • Scope to cut first: optional polish/additional examples; preserve scientific validity.
  • If the forecast exceeds available time: record a concrete reduced scope or revised delivery proposal before committing.

Peter's commitment / adjustments: pending. Reviewing model and date: pending.

evidence.md open ↗

Execution state: NOT_STARTED. Specification This file is a blank register with planned artifact names; none of the rows prove completion.

Item Path / URL / version State Verification / actual result Verified by / date
agreement-report.md Not created NOT_STARTED Pending: Pre-adjudication labels are retained and agreement is reported by field and support. —
descriptive-analysis.md Not created NOT_STARTED Pending: Exploratory comparisons are labeled; no causal or cross-product efficacy claims. —
figure-inventory.md Not created NOT_STARTED Pending: One command regenerates each plot and caption N agrees with the table. —
Learning exercise / Peter's quiz Not created NOT_STARTED Peter's actual answers required —
Founder paper digest Not created NOT_STARTED Source/content and access checked —
Branding pack Not created NOT_STARTED Claims audited; drafted/public status distinct —
Opportunity actions Not created NOT_STARTED Drafted/sent/replied/booked/held distinct —

Reproduction and scientific measurements

Question / metric Dataset, N and unit Split / seed / config Command or verification method Output path and measured value Uncertainty / limitation

External events, when authorized and actually performed

Date Action / counterpart Receipt or private reference State Next action / date

Actual learning and decisions

Peter's teach-back / quiz score: not assessed. Scientific assumptions and deviations: none recorded yet. Budget allocated / spent: not assessed / no spend recorded. Missing evidence and responsible owner: pending inspection.

Do not put API keys, source full texts with restricted rights, client data or invoice personal details in a public version of this register. Keep private evidence references private.

review.md open ↗

Review status: NOT_REVIEWED. Specification · Evidence

What was actually completed?

  • ☐ Pre-adjudication labels are retained and agreement is reported by field and support. Evidence: pending.
  • ☐ Exploratory comparisons are labeled; no causal or cross-product efficacy claims. Evidence: pending.
  • ☐ One command regenerates each plot and caption N agrees with the table. Evidence: pending.
  • ☐ Learning assessed from Peter's actual answers. Evidence: pending.
  • ☐ Branding/opportunity states recorded correctly. Evidence: pending.

Learning and outcome

What Peter can explain or reproduce now: not assessed. Quiz / teach-back gaps: not assessed. Measured result and limitations: pending. Best evidence link for a scientist/recruiter/buyer: pending. What failed or changed, and why: pending.

Gate and capacity

Gate requirement: No standalone gate; check this week's acceptance criteria and next gate dependencies. Gate status: NOT_STARTED. Original target week: See next gate in specs. Actual completion date / forecast: not set. Missing external evidence: pending inspection. Blocks completed / 7: not recorded. Days with commits / 7: not recorded. Sunday build log / optional Wednesday note: not recorded. Founder conversations cumulative: not recorded. Earned evidence level and proof: not assessed. Consecutive lost weeks: not assessed.

Week-specific risk to revisit: Kappa is not an agreement statistic for continuous raw measurements without justified categorization. If the second annotator is delayed, agreement stays pending and downstream release limitations must be explicit.

Decision and next-model handoff

Continue / recover / blocked: not decided. Retain as the minimum: kappa. Skipped permanently with reason: none recorded. Carryover with owner, dependency and target week: none recorded. Canonical repository paths and versions: pending. Data permissions, split definitions or assumptions to preserve: pending. External action authorization that still applies: not assessed. Next physical action, exact file/function/paragraph: pending. Updates to root PROGRESS / LOG / TODAY completed: ☐

Next week

✎

YOUR SPACE

Notes, links & media

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    ⏱ Focus Focus25:00 0 min today