Uri Alon's talk and essay on "the cloud" in research
Saturday sandbox
Uri Alon's talk and essay on "the cloud" in research (iBiology; verify)
In: LABLOOP-W40 Notebook
WEEK 40 · Mon 21 Jun → Sun 27 Jun 2027
UNDERSTAND · PRACTICE · KEEP EVIDENCE
Read the week in plain language, refresh the foundations, follow each challenge step by step, and check what evidence to keep. Includes worked examples, answer keys and prompts for visual study resources.
Use this within your existing weekly blocks. Your learning completion and research evidence remain in your current tracker and week files.
START HERE · 2 MINUTES
STATUS
| Deliverable | Acceptance | State |
|---|---|---|
final-evidence-audit.mdBuild create + |
Audit all paper, release, talk, collaboration and engagement evidence; separate submitted/public/accepted and invoiced/received income. Acceptance: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit. | |
career-decision.mdBuild create + |
Compare consulting, employment and hybrid options using actual offers/pipeline, income, capacity, scientific growth and the culture filter. Acceptance: The choice and its reasoning are written; no offer is invented. | |
next-90-days.mdBuild create + |
Prepare the public retro and a 90-day continuation with ongoing pilot dates, journal revisions, next research question and hiring actions. Acceptance: Owners and next dates cover every open commitment beyond week 40. | |
study-notes.mdLearning create + |
Selected exact free resources; bounded lesson/exercise; separate solution; quiz and grading rubric; Peter's answers and gaps when executed | |
founder-paper.mdFounder papers create + |
Verified source and P11 digest; authentic question and connection sentence; access limitations | |
branding-pack.mdBranding create + |
Wednesday note, Sunday build log, X adaptation, figure/caption/alt text and the week's special asset; each claim linked to real proof | |
opportunity-actions.mdOpportunities create + |
Qualified target/role, source/date, ladder stage, next action, message/interview/proposal draft and actual status | |
evidence.mdEvidence & review open & edit ↗ |
Actual paths/URLs, versions, checks/metrics, preparation versus execution state and external receipts when applicable | |
review.mdEvidence & review open & edit ↗ |
Checklist, learning assessment, gate status, shortfalls, next actions and carryover |
These filenames are outputs to prepare during this week's execution; this scaffold does not claim they already exist. Drafts and measured results have different states. Technical code/data stay in the canonical project repository and are referenced from these coordinating files.
During preparation, future measured tables get column definitions, input requirements and run instructions with PENDING status. During execution, replace pending values only with measured outputs. Do not create realistic-looking fake evidence.
600 MINUTES MAXIMUM
Target. Audit all paper, release, talk, collaboration and engagement evidence; separate submitted/public/accepted and invoiced/received income. Stop when: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit.
No material for Monday — this is a pure build day. Need something to study instead? →
Target. No new course. Review the forty-week evidence and unresolved learning gaps. Produce: One concise applied note, a worked decision/example and unresolved questions.
No material for Tuesday — this is a pure build day. Need something to study instead? →
Target. Compare consulting, employment and hybrid options using actual offers/pipeline, income, capacity, scientific growth and the culture filter. Stop when: The choice and its reasoning are written; no offer is invented. Reserve the last 10 minutes for the optional Wednesday note.
No material for Wednesday — this is a pure build day. Need something to study instead? →
Target. Compare actual career options, rehearse the scientific narrative and prepare the next 90 days. Apply the Half 2 one-formal-study-block rule.
No material for Thursday — this is a pure build day. Need something to study instead? →
Target. Prepare the public retro and a 90-day continuation with ongoing pilot dates, journal revisions, next research question and hiring actions. Stop when: Owners and next dates cover every open commitment beyond week 40.
No material for Friday — this is a pure build day. Need something to study instead? →
Target. Resolve the earliest critical spillover or dependency. Prepare any long-form publication draft from existing figures here if needed. Sandbox only after commitments are met.
Optional, only if the day went well:
Target. 20 min build-log draft/publication when authorized; 5 min evidence/checklist; 20 min source-grounded gap review; 15 min next week's six physical actions.
No material for Sunday — this is a pure build day. Need something to study instead? →
Spare pockets, repo exercises and anything the plan lists without a day. Take them in this order when a day finishes early.
The model must turn these into exact physical actions using the observed files and available inputs. Each 90-minute block includes start/stop rituals. All calls, posts, debugging, reading and exercises consume this same capacity.
Half 2: Tuesday is the formal study block unless this is a selling/submission/decision week. Thursday supports applied review, partner work or the market task; do not add another full course.
WHAT TO WATCH, READ AND RUN
Stanford's Designing Your Life course has a simple idea: you do not find your path by thinking harder; you find it by prototyping lives and then choosing among real options. That is what the last 40 weeks were, whether you noticed or not: prototypes of a scientist's life (papers), a consultant's life (audits), and an employee's life (interviews). This week you look at the evidence, not the mood. Gauge level. Income …
0 of 6 finished · give me one to start now → · open in the deck →
In the plan's running order: each card says which block it belongs to and what has to come before it. The seven-day plan lists the same cards under the day that owns them.
Saturday sandbox
Uri Alon's talk and essay on "the cloud" in research (iBiology; verify)
In: LABLOOP-W40 Notebook
Saturday sandbox · after Uri Alon's talk and essay on "the cloud" in research
Stanford Designing Your Life resources (designingyour.life) — odyssey plan worksheets
In: LABLOOP-W40 Notebook
Bill Burnett & Dave Evans, Designing Your Life (book, paid) — chapters on "odyssey plans" and "choosing well"; or Bill Burnett's TEDx talk "Designing Your Life" (YouTube, free) (30 min)
In: LABLOOP-W40 Notebook
Richard Hamming, You and Your Research (final re-read; compare your week 0 notes) (30 min)
In: LABLOOP-W40 Notebook
Script that counts blocks, lost weeks and gates from LOG.md and PROGRESS.md; the only dashboard you ever need
In: LABLOOP-W40 Notebook
One-page interactive "40 weeks" timeline for the public retro
In: LABLOOP-W40 Notebook
READ FIRST
This week delivers the three concrete artifacts below and the supporting learning/branding/opportunity pack. The scientific or commercial outcome follows the preserved source brief, while the acceptance checks make its evidence testable. The career objective is to turn this work into something a scientist, hiring manager or buyer can inspect.
READ FIRST
Read v6 · Week 40 · GATE 40: retro and decision before Monday. It expands this week's one-row v5 brief into daily build steps and adds the Welcome analogy, Learn it (▶ core and + deeper sources), Run it (repos with a 20-40 minute exercise), the NotebookLM kit and the mentor check below. Standing v6 rules: resource rules, NotebookLM protocol, chapter anatomy. v6 adds depth only; it does not change a goal, gate, output or the 600-minute cap, so this specification still governs execution.
Act VIII (finale) · Threads: all · GATE 40
Where this week sits. - ← From: everything. - → Feeds: Half 3 (month 10+): retainers, fractional role, or a new job; L6 "used" as others adopt FermLit and batchlens. - ⟳ Returns in: your next plan, which starts from evidence rather than from zero.
Goals. - 🎯 This week: retro with gauge, income, pipeline and offers; written decision; public retro. - 🏁 This gate (40): see the pass criteria below. - 🌟 Final: you are, verifiably, an AI scientist for biotech with a practice or a role of your choosing.
The plan (from v5 Part 7, expanded; gate and output unchanged).
v5 row: 40 | GATE 40: retro and decision | none | Gauge level, income to date, pipeline, offers. Decide: consultant with retainers, or employee, or both | Public retro - Goal: a decision written down, backed by evidence. - Build: Mon: evidence table: every gate, artifact link, DOI, date; gauge level; income; pipeline; offers; lost weeks. Wed: decision memo (one page): options, evidence for each, culture filter scores, energy log patterns, what you choose and what you stop. Fri: public retro (LinkedIn article + site): what worked, what failed, what you would tell someone starting week 0. - Sun: public retro posted. Plan Half 3 in one page, no more. - Gate 40 passes when: three preprints (one co-authored), two journal submissions, one JOSS submission, three instruments with DOIs, one talk delivered, at least one paid engagement delivered, and a decision written down. - Only one thing: the decision memo.
Mentor check. "I know what I built, what it proved, what people paid for, and where I am going next. It is written down."
OPEN WHEN NEEDED
READ FIRST
Material: No new course. Review the forty-week evidence and unresolved learning gaps.
Produce: One concise applied note, a worked decision/example and unresolved questions.
Understanding check: The note directly supports this week's experiment, collaboration, delivery or career action.
During preparation, write one worked example connected to the week's actual task, one exercise with a separate answer key and five questions. Peter supplies answers; score explanation quality and flag misconceptions in QUESTIONS. Numeric/scientific conclusions require actual data or explicitly synthetic teaching values.
Material: Compare actual career options, rehearse the scientific narrative and prepare the next 90 days.
Produce: One concise applied note, a worked decision/example and unresolved questions.
Understanding check: The note directly supports this week's experiment, collaboration, delivery or career action.
Use the prompt pack: P1 explanation ladder, P2 concept-to-project bridge and P3 quiz. Coding practice belongs within the allocated study/build block. Where the source asks for a favorable scientific result, substitute an honest measured comparison as explained below.
Select one verified founder/scientific-lead paper relevant to this week's domain. Use P11; save the question, method, numerical result with context, data workflow, three author questions and one connection sentence in founder-paper.md. Keep abstract-only access limitations explicit. On source weeks with no study, prioritize the commercial/submission task and log any skipped digest.
OPEN WHEN NEEDED
Branding: Prepare final portfolio/CV/LinkedIn refresh with an accurate scientist-development narrative and links to earned proof.
Opportunity action: Close or schedule every live opportunity; define income and role acceptance criteria from Peter's stated preferences and actual terms.
Use career asset contracts. Publish at most the agreed cadence; one figure and one supported number or admitted failure can support multiple drafts. In long-form weeks, prepare a 1,500–2,500-word article from existing evidence within the build/buffer allocation. In release/demo weeks, prepare a 60-second script: problem, input, command/action, result, limitation and proof link.
Verify individuals, jobs and affiliations at execution time. The GridX list and v4 company map are research seeds, not current facts. Do not reveal named company weaknesses or employer/client confidential information. Keep drafted/sent/replied/booked/held statuses separate. The planning request alone does not authorize external messages or publication; honor explicit authorization in the execution session.
OPEN WHEN NEEDED
Completion targets include three preprints (one co-authored), two journal submissions, one JOSS submission, three instrument DOIs, a delivered talk and paid engagement. If any are unmet, record an incomplete gate and a recovery route; an early suitable job can be a valid alternative outcome per v5.
Apply the root scientific evidence contract: provenance; meaningful independent splits; no future-data leakage; baseline comparison; actual denominators/uncertainty; failed cases; human review where required. State whether data are simulated, public experimental, synthetic or partner-provided.
Keep source gates intact, and log scope/time conflicts in review. Missing people, money, access or results must not be replaced with invented evidence. Reduce optional polish first. A specific essential external dependency stays pending while independent preparation continues.
READ FIRST
This is Gate 40: Evidence and decision.
Required proof: Three public preprints, one co-authored; two journal submissions; one JOSS submission; batchlens/trialkit/labdocs release DOIs; one delivered talk; at least one paid engagement delivered; written career decision.
Reputation interpretation: L5 only with actual reviewed/accepted and invited evidence. Record target, forecast, actual date and evidence link. The original gate stays incomplete until the required external proof exists.
READ FIRST
Expanded minimum derived from the source goal: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit.
Operational first step if stalled: open final-evidence-audit.md, write the required inputs and produce the smallest checkable example in ten minutes. If a more urgent missing gate dependency controls the week, use the source minimum above.
If the full week does not fit, use P14: retain one gate-critical deliverable and one directly supporting study exercise; record what is skipped versus moved. Do not mark the original full gate passed merely because the minimum was completed. After a missed week, reforecast from actual evidence and avoid a second unexamined lost week.
OPEN WHEN NEEDED
In review, state exactly what exists, what was verified, what Peter can now explain, which external events remain pending, where the canonical code/data live, and the next file/function or draft paragraph to touch. Link each fact to evidence. Carry scientific assumptions, split definitions and rights constraints forward explicitly.
OPEN WHEN NEEDED
Prepare Week 40 of this LABLOOP execution plan.
Read execution-plan/specs.md, execution-plan/DECISIONS.md,
execution-plan/GATES.md and
execution-plan/weeks/week-40-final-retrospective-and-career-decision/specs.md, commitment.md, evidence.md and review.md.
Read prior prerequisite reviews and inspect actual repository/data state.
Use v5 as the governing sequence, the v6 Week 40 chapter
(LABLOOP-Master-Plan-v6.md) as the deeper walkthrough, and v4 only for
retained details.
Produce the full local preparation pack and the exact week-specific files named
in the artifact table. Give me a bounded lesson with exercises/answer key,
daily physical actions, technical runbook or draft, branding drafts and
career/commercial actions. Keep the total to 600 minutes.
Separate prepared artifacts from measured results and my learning completion.
Verify sources and do not invent metrics, citations, papers, people or outcomes.
Do not execute external communications, publication or spending unless the
current session already authorizes the specific action.
Finish by updating evidence/review and TODAY with the next physical action.
OPEN WHEN NEEDED
v6 expands this row into a full brief, with the gate and output unchanged, inside v6 · Week 40 · GATE 40: retro and decision. The following is source planning text, not a claim of completion. Apply the explicit evidence corrections in this specification and DECISIONS.md.
| Week | Goal | Study (Tue) | Build (Mon/Wed/Fri) | Output |
|---|---|---|---|---|
| 40 | GATE 40: retro and decision | none | Gauge level, income to date, pipeline, offers. Decide: consultant with retainers, or employee, or both | Public retro |
WEEK FILES
State: UNCONFIRMED. Owner: Peter Ciancaglini. Specification
Start date: not set. End date: not set. Available hours: confirm (planned ceiling 10). Primary outcome: final retrospective and career decision. Minimum that keeps the next gate alive: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit.
final-evidence-audit.md: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit.career-decision.md: The choice and its reasoning are written; no offer is invented.next-90-days.md: Owners and next dates cover every open commitment beyond week 40.| Day | Minutes | Physical action / outcome | Actual slot | Done |
|---|---|---|---|---|
| Mon | 90 | Audit all paper, release, talk, collaboration and engagement evidence; separate submitted/public/accepted and invoiced/received income. | Not set | ☐ |
| Tue | 90 | One concise applied note, a worked decision/example and unresolved questions. | Not set | ☐ |
| Wed | 90 | Compare consulting, employment and hybrid options using actual offers/pipeline, income, capacity, scientific growth and the culture filter. Last ten minutes: optional note. | Not set | ☐ |
| Thu | 90 | One concise applied note, a worked decision/example and unresolved questions. Include relevant founder-paper work within this block. | Not set | ☐ |
| Fri | 90 | Prepare the public retro and a 90-day continuation with ongoing pilot dates, journal revisions, next research question and hiring actions. | Not set | ☐ |
| Sat | 90 | Resolve critical spillover; long-form draft if due; sandbox only if done. | Not set | ☐ |
| Sun | 60 | Build log, evidence, gap review, next actions. | Not set | ☐ |
Peter's commitment / adjustments: pending. Reviewing model and date: pending.
Execution state: NOT_STARTED. Specification This file is a blank register with planned artifact names; none of the rows prove completion.
| Item | Path / URL / version | State | Verification / actual result | Verified by / date |
|---|---|---|---|---|
| final-evidence-audit.md | Not created | NOT_STARTED | Pending: Every source gate has a supported status and unresolved dependencies are visible. | — |
| career-decision.md | Not created | NOT_STARTED | Pending: The choice and its reasoning are written; no offer is invented. | — |
| next-90-days.md | Not created | NOT_STARTED | Pending: Owners and next dates cover every open commitment beyond week 40. | — |
| Learning exercise / Peter's quiz | Not created | NOT_STARTED | Peter's actual answers required | — |
| Founder paper digest | Not created | NOT_STARTED | Source/content and access checked | — |
| Branding pack | Not created | NOT_STARTED | Claims audited; drafted/public status distinct | — |
| Opportunity actions | Not created | NOT_STARTED | Drafted/sent/replied/booked/held distinct | — |
| Gate 40 | No evidence | NOT_STARTED | Three public preprints, one co-authored; two journal submissions; one JOSS submission; batchlens/trialkit/labdocs release DOIs; one delivered talk; at least one paid engagement delivered; written career decision. | — |
| Question / metric | Dataset, N and unit | Split / seed / config | Command or verification method | Output path and measured value | Uncertainty / limitation |
|---|---|---|---|---|---|
| Date | Action / counterpart | Receipt or private reference | State | Next action / date |
|---|---|---|---|---|
Peter's teach-back / quiz score: not assessed. Scientific assumptions and deviations: none recorded yet. Budget allocated / spent: not assessed / no spend recorded. Missing evidence and responsible owner: pending inspection.
Do not put API keys, source full texts with restricted rights, client data or invoice personal details in a public version of this register. Keep private evidence references private.
Review status: NOT_REVIEWED. Specification · Evidence
What Peter can explain or reproduce now: not assessed. Quiz / teach-back gaps: not assessed. Measured result and limitations: pending. Best evidence link for a scientist/recruiter/buyer: pending. What failed or changed, and why: pending.
Gate requirement: Three public preprints, one co-authored; two journal submissions; one JOSS submission; batchlens/trialkit/labdocs release DOIs; one delivered talk; at least one paid engagement delivered; written career decision. Gate status: NOT_STARTED. Original target week: 40. Actual completion date / forecast: not set. Missing external evidence: pending inspection. Blocks completed / 7: not recorded. Days with commits / 7: not recorded. Sunday build log / optional Wednesday note: not recorded. Founder conversations cumulative: not recorded. Earned evidence level and proof: not assessed. Consecutive lost weeks: not assessed.
Week-specific risk to revisit: Completion targets include three preprints (one co-authored), two journal submissions, one JOSS submission, three instrument DOIs, a delivered talk and paid engagement. If any are unmet, record an incomplete gate and a recovery route; an early suitable job can be a valid alternative outcome per v5.
Continue / recover / blocked: not decided. Retain as the minimum: Write the evidence audit, career decision and next 90 days from actual outcomes, with every unmet gate and ongoing commitment explicit. Skipped permanently with reason: none recorded. Carryover with owner, dependency and target week: none recorded. Canonical repository paths and versions: pending. Data permissions, split definitions or assumptions to preserve: pending. External action authorization that still applies: not assessed. Next physical action, exact file/function/paragraph: pending. Updates to root PROGRESS / LOG / TODAY completed: ☐
YOUR SPACE