Europe PMC REST API docs
Monday build block · Read it inside Monday's build block
Build-block reading · Europe PMC REST API docs — europepmc.org/RestfulWebService (search syntax, OPEN_ACCESS:y, fullTextXML)
In: LABLOOP-W05 Notebook
WEEK 05 · Mon 19 Oct → Sun 25 Oct 2026
UNDERSTAND · PRACTICE · KEEP EVIDENCE
Read the week in plain language, refresh the foundations, follow each challenge step by step, and check what evidence to keep. Includes worked examples, answer keys and prompts for visual study resources.
Use this within your existing weekly blocks. Your learning completion and research evidence remain in your current tracker and week files.
START HERE · 2 MINUTES
STATUS
| Deliverable | Acceptance | State |
|---|---|---|
related-work.mdBuild create + |
Verify at least ten related works and decide whether FermLit is a new resource or an extension; record search strings and date. Acceptance: Every citation resolves and the novelty statement follows the evidence. | |
corpus-protocol.mdBuild create + |
Pilot the parenthesized Europe PMC query, screen eligibility and acquire up to the 500-paper target with a license-aware manifest. Acceptance: Retrieved, eligible, accessible and included counts are separately reported. | |
schema-review.mdBuild create + |
Define experiment-level records and provenance fields; hand-map three papers with multiple conditions; save raw and normalized units. Acceptance: Schema distinguishes paper, experiment, missing, not reported, and extraction failed. | |
study-notes.mdLearning create + |
Selected exact free resources; bounded lesson/exercise; separate solution; quiz and grading rubric; Peter's answers and gaps when executed | |
founder-paper.mdFounder papers create + |
Verified source and P11 digest; authentic question and connection sentence; access limitations | |
branding-pack.mdBranding create + |
Wednesday note, Sunday build log, X adaptation, figure/caption/alt text and the week's special asset; each claim linked to real proof | |
opportunity-actions.mdOpportunities create + |
Qualified target/role, source/date, ladder stage, next action, message/interview/proposal draft and actual status | |
evidence.mdEvidence & review open & edit ↗ |
Actual paths/URLs, versions, checks/metrics, preparation versus execution state and external receipts when applicable | |
review.mdEvidence & review open & edit ↗ |
Checklist, learning assessment, gate status, shortfalls, next actions and carryover |
These filenames are outputs to prepare during this week's execution; this scaffold does not claim they already exist. Drafts and measured results have different states. Technical code/data stay in the canonical project repository and are referenced from these coordinating files.
During preparation, future measured tables get column definitions, input requirements and run instructions with PENDING status. During execution, replace pending values only with measured outputs. Do not create realistic-looking fake evidence.
600 MINUTES MAXIMUM
Target. Verify at least ten related works and decide whether FermLit is a new resource or an extension; record search strings and date. Stop when: Every citation resolves and the novelty statement follows the evidence.
Do these in this order — the plan's own sequence:
Target. *Biology 2e* ch. 14 (DNA), 15 (genes and proteins); Crash Course "DNA, Hot Pockets & the Longest Word Ever" Produce: Notes; Rosalind problems 1-4 (rosalind.info)
Do these in this order — the plan's own sequence:
Target. Pilot the parenthesized Europe PMC query, screen eligibility and acquire up to the 500-paper target with a license-aware manifest. Stop when: Retrieved, eligible, accessible and included counts are separately reported. Reserve the last 10 minutes for the optional Wednesday note.
No material for Wednesday — this is a pure build day. Need something to study instead? →
Target. ISLP ch. 6.1-6.2 and ch. 8 (trees, boosting) Select material/exercise that fits 60 minutes; use the last 30 for the founder paper.
Do these in this order — the plan's own sequence:
Target. Define experiment-level records and provenance fields; hand-map three papers with multiple conditions; save raw and normalized units. Stop when: Schema distinguishes paper, experiment, missing, not reported, and extraction failed.
No material for Friday — this is a pure build day. Need something to study instead? →
Target. Resolve the earliest critical spillover or dependency. Prepare any long-form publication draft from existing figures here if needed. Sandbox only after commitments are met.
Optional, only if the day went well:
Target. 20 min build-log draft/publication when authorized; 5 min evidence/checklist; 20 min source-grounded gap review; 15 min next week's six physical actions.
No material for Sunday — this is a pure build day. Need something to study instead? →
Spare pockets, repo exercises and anything the plan lists without a day. Take them in this order when a day finishes early.
The model must turn these into exact physical actions using the observed files and available inputs. Each 90-minute block includes start/stop rituals. All calls, posts, debugging, reading and exercises consume this same capacity.
The source lists more material than necessarily fits. Select exact excerpts for the learning objective and park the remainder; no full-course completion requirement.
WHAT TO WATCH, READ AND RUN
Every serious research project starts with an uncomfortable question: has somebody already done this? In corporate strategy you would call it a competitive scan. In science it is the related-work search, and skipping it is the most common way a newcomer wastes six months. So the first thing FermLit does is look for its own twin. If a fermentation-literature dataset already exists, wonderful: you extend it and cite i…
0 of 16 finished · give me one to start now → · open in the deck →
In the plan's running order: each card says which block it belongs to and what has to come before it. The seven-day plan lists the same cards under the day that owns them.
Monday build block · Read it inside Monday's build block
Build-block reading · Europe PMC REST API docs — europepmc.org/RestfulWebService (search syntax, OPEN_ACCESS:y, fullTextXML)
In: LABLOOP-W05 Notebook
OpenStax Biology 2e ch. 14 (DNA structure and function) + ch. 15 (genes and proteins), sections 14.1-14.3, 15.1-15.5 (60 min)
In: LABLOOP-W05 Notebook
Tuesday · after OpenStax Biology 2e
Crash Course Biology #11 "DNA, Hot Pockets, & The Longest Word Ever" (YouTube, 13 min)
In: LABLOOP-W05 Notebook
Tuesday · after Crash Course Biology #11 "DNA, Hot Pockets, & The Longest Word Ever"
Rosalind problems 1-4 (rosalind.info)
In: LABLOOP-W05 Notebook
ISLP ch. 6.1-6.2 (subset selection, ridge, lasso) and ch. 8 (trees, bagging, boosting) (75 min, skim the proofs)
In: LABLOOP-W05 Notebook
Saturday sandbox
Dagdelen et al. (2024), "Structured information extraction from scientific text with large language models", Nature Communications 15:1418. The closest methodological cousin of FermLit (materials science). Read it this week; you will cite it
In: LABLOOP-W05 Notebook
Saturday sandbox · after Dagdelen et al. (2024), "Structured information extraction from scientific text with large langu…
Polak & Morgan (2024), "Extracting accurate materials data from research papers with conversational language models and prompt engineering", Nature Communications 15:1569
In: LABLOOP-W05 Notebook
Saturday sandbox · after Polak & Morgan
Uri Alon (2009), "How to choose a good scientific problem" (re-read from week 0, now with FermLit in mind)
In: LABLOOP-W05 Notebook
Saturday sandbox · after Uri Alon (2009), "How to choose a good scientific problem"
Coursera Biology Meets Programming: Bioinformatics for Beginners (UCSD), week 1, if Rosalind hooks you
In: LABLOOP-W05 Notebook
Saturday sandbox · after Coursera Biology Meets Programming: Bioinformatics for Beginners
MIT 7.00x (edX), molecular biology unit, for Lander's storytelling of the central dogma
In: LABLOOP-W05 Notebook
StatQuest "Regularization Part 1: Ridge (L2) Regression" and "Gradient Boost Part 1: Regression Main Ideas" (YouTube, 25 min)
In: LABLOOP-W05 Notebook
Query OpenAlex for works on "fed-batch fermentation titer" per year; plot counts. Tells you the size of the ocean before you fish
In: LABLOOP-W05 Notebook
Search Semantic Scholar for "literature-derived fermentation dataset"; save the top 20 to RELATED.md with citation counts
In: LABLOOP-W05 Notebook
Parse one PMC OA XML into title, abstract, methods paragraphs; this becomes corpus/parse.py
In: LABLOOP-W05 Notebook
Read the README and run the quickstart example: extraction with source grounding (every value mapped to its exact span). This is the provenance idea FermLit needs, already implemented
In: LABLOOP-W05 Notebook
Colab: Ch08-baggboost-lab.ipynb (trees and boosting)
In: LABLOOP-W05 Notebook
READ FIRST
This week delivers the three concrete artifacts below and the supporting learning/branding/opportunity pack. The scientific or commercial outcome follows the preserved source brief, while the acceptance checks make its evidence testable. The career objective is to turn this work into something a scientist, hiring manager or buyer can inspect.
READ FIRST
Read v6 · Week 5 · FermLit begins: the corpus before Monday. It carries this week's v5 brief unchanged and adds the Welcome analogy, Learn it (▶ core and + deeper sources), Run it (repos with a 20-40 minute exercise), the NotebookLM kit and the mentor check below. Standing v6 rules: resource rules, NotebookLM protocol, chapter anatomy. v6 adds depth only; it does not change a goal, gate, output or the 600-minute cap, so this specification still governs execution.
Act II · Threads: B, M, FL · Next gate: 8
Where this week sits.
- ← From: week 4 reproducibility habits (manifest, checksums); your v3/Vara experience with LLM pipelines.
- → Feeds: week 6 (the schema becomes annotation guidelines), week 7 (the agent fills the schema), week 9 (corpus scales to 2,000), week 14 (RELATED.md becomes Paper 1's related work).
- ⟳ Returns in: Paper 1 Methods: "Corpus construction" and "Schema".
Goals.
- 🎯 This week: RELATED.md with ≥ 10 verified references; 500 open-access XMLs + manifest; fermlit.schema.json v0 that fits three hand-annotated papers.
- 🏁 Next milestone: Gate 8 (technical report on Zenodo, F1 table public).
- 🌟 Final: Paper 1 on bioRxiv (wk 16) and a dataset other scientists cite (L6).
Mentor check. "I know whether FermLit is novel or an extension, and I can defend every field in my schema."
OPEN WHEN NEEDED
READ FIRST
Source unit: B5 · DNA to protein
Material: Biology 2e ch. 14 (DNA), 15 (genes and proteins); Crash Course "DNA, Hot Pockets & the Longest Word Ever"
Produce: Notes; Rosalind problems 1-4 (rosalind.info)
Understanding check: You can read "the strain overexpresses gene X" and know what it means
During preparation, write one worked example connected to the week's actual task, one exercise with a separate answer key and five questions. Peter supplies answers; score explanation quality and flag misconceptions in QUESTIONS. Numeric/scientific conclusions require actual data or explicitly synthetic teaching values.
Source unit: M5 · Regularization and trees
Material: ISLP ch. 6.1-6.2 and ch. 8 (trees, boosting)
Produce: LightGBM soft sensor with tuned regularization
Understanding check: You can explain why boosting wins on tabular data
Use the prompt pack: P1 explanation ladder, P2 concept-to-project bridge and P3 quiz. Coding practice belongs within the allocated study/build block. Where the source asks for a favorable scientific result, substitute an honest measured comparison as explained below.
Select one verified founder/scientific-lead paper relevant to this week's domain. Use P11; save the question, method, numerical result with context, data workflow, three author questions and one connection sentence in founder-paper.md. Keep abstract-only access limitations explicit. On source weeks with no study, prioritize the commercial/submission task and log any skipped digest.
OPEN WHEN NEEDED
Branding: Draft schema explainer and novelty boundary using actual included-paper counts.
Opportunity action: Use the weekly founder digest to find a potential domain reviewer; begin searching for the independent annotator needed by week 10.
Use career asset contracts. Publish at most the agreed cadence; one figure and one supported number or admitted failure can support multiple drafts. In long-form weeks, prepare a 1,500–2,500-word article from existing evidence within the build/buffer allocation. In release/demo weeks, prepare a 60-second script: problem, input, command/action, result, limitation and proof link.
Verify individuals, jobs and affiliations at execution time. The GridX list and v4 company map are research seeds, not current facts. Do not reveal named company weaknesses or employer/client confidential information. Keep drafted/sent/replied/booked/held statuses separate. The planning request alone does not authorize external messages or publication; honor explicit authorization in the execution session.
OPEN WHEN NEEDED
Do not equate search hits with fermentation experiments. Scientific Data claims and company gaps are hypotheses. Freeze paper-level development/test partitions before annotation or prompt tuning.
Apply the root scientific evidence contract: provenance; meaningful independent splits; no future-data leakage; baseline comparison; actual denominators/uncertainty; failed cases; human review where required. State whether data are simulated, public experimental, synthetic or partner-provided.
Keep source gates intact, and log scope/time conflicts in review. Missing people, money, access or results must not be replaced with invented evidence. Reduce optional polish first. A specific essential external dependency stays pending while independent preparation continues.
READ FIRST
This is an enabling week. Its deliverables feed the next scheduled gate: 8. Complete the acceptance checklist below; do not promote reputation from a draft.
READ FIRST
Source-preserving minimum: RELATED.md. If someone did it already, you must know now.
Operational first step if stalled: open related-work.md, write the required inputs and produce the smallest checkable example in ten minutes. If a more urgent missing gate dependency controls the week, use the source minimum above.
If the full week does not fit, use P14: retain one gate-critical deliverable and one directly supporting study exercise; record what is skipped versus moved. Do not mark the original full gate passed merely because the minimum was completed. After a missed week, reforecast from actual evidence and avoid a second unexamined lost week.
OPEN WHEN NEEDED
In review, state exactly what exists, what was verified, what Peter can now explain, which external events remain pending, where the canonical code/data live, and the next file/function or draft paragraph to touch. Link each fact to evidence. Carry scientific assumptions, split definitions and rights constraints forward explicitly.
OPEN WHEN NEEDED
Prepare Week 05 of this LABLOOP execution plan.
Read execution-plan/specs.md, execution-plan/DECISIONS.md,
execution-plan/GATES.md and
execution-plan/weeks/week-05-fermlit-corpus-and-schema/specs.md, commitment.md, evidence.md and review.md.
Read prior prerequisite reviews and inspect actual repository/data state.
Use v5 as the governing sequence, the v6 Week 05 chapter
(LABLOOP-Master-Plan-v6.md) as the deeper walkthrough, and v4 only for
retained details.
Produce the full local preparation pack and the exact week-specific files named
in the artifact table. Give me a bounded lesson with exercises/answer key,
daily physical actions, technical runbook or draft, branding drafts and
career/commercial actions. Keep the total to 600 minutes.
Separate prepared artifacts from measured results and my learning completion.
Verify sources and do not invent metrics, citations, papers, people or outcomes.
Do not execute external communications, publication or spending unless the
current session already authorizes the specific action.
Finish by updating evidence/review and TODAY with the next physical action.
OPEN WHEN NEEDED
v6 reproduces this brief unchanged inside v6 · Week 5 · FermLit begins: the corpus. The following is source planning text, not a claim of completion. Apply the explicit evidence corrections in this specification and DECISIONS.md.
fermlit/RELATED.md with what you found (this decides "novel" vs "extension"). Done when the file has ≥ 10 verified references. Wed: Europe PMC query ("fed-batch" OR "fermentation" AND ("titer" OR "titre") AND OPEN_ACCESS:y, refine), download full-text XML for 500 papers. Done when 500 XML files and a manifest exist. Fri: schema/fermlit.schema.json v0: organism, strain, product, reactor type, working volume, mode (batch/fed-batch/continuous), medium carbon source, temperature, pH, DO setpoint, feed strategy, duration, final titer (g/L), yield, productivity, scale, plus a provenance sentence per field. Done when three papers annotated by hand against it fit.RELATED.md. If someone did it already, you must know now.WEEK FILES
State: UNCONFIRMED. Owner: Peter Ciancaglini. Specification
Start date: not set. End date: not set. Available hours: confirm (planned ceiling 10).
Primary outcome: fermlit corpus and schema.
Minimum that keeps the next gate alive: RELATED.md. If someone did it already, you must know now.
related-work.md: Every citation resolves and the novelty statement follows the evidence.corpus-protocol.md: Retrieved, eligible, accessible and included counts are separately reported.schema-review.md: Schema distinguishes paper, experiment, missing, not reported, and extraction failed.| Day | Minutes | Physical action / outcome | Actual slot | Done |
|---|---|---|---|---|
| Mon | 90 | Verify at least ten related works and decide whether FermLit is a new resource or an extension; record search strings and date. | Not set | ☐ |
| Tue | 90 | Notes; Rosalind problems 1-4 (rosalind.info) | Not set | ☐ |
| Wed | 90 | Pilot the parenthesized Europe PMC query, screen eligibility and acquire up to the 500-paper target with a license-aware manifest. Last ten minutes: optional note. | Not set | ☐ |
| Thu | 90 | LightGBM soft sensor with tuned regularization Include relevant founder-paper work within this block. | Not set | ☐ |
| Fri | 90 | Define experiment-level records and provenance fields; hand-map three papers with multiple conditions; save raw and normalized units. | Not set | ☐ |
| Sat | 90 | Resolve critical spillover; long-form draft if due; sandbox only if done. | Not set | ☐ |
| Sun | 60 | Build log, evidence, gap review, next actions. | Not set | ☐ |
Peter's commitment / adjustments: pending. Reviewing model and date: pending.
Execution state: NOT_STARTED. Specification This file is a blank register with planned artifact names; none of the rows prove completion.
| Item | Path / URL / version | State | Verification / actual result | Verified by / date |
|---|---|---|---|---|
| related-work.md | Not created | NOT_STARTED | Pending: Every citation resolves and the novelty statement follows the evidence. | — |
| corpus-protocol.md | Not created | NOT_STARTED | Pending: Retrieved, eligible, accessible and included counts are separately reported. | — |
| schema-review.md | Not created | NOT_STARTED | Pending: Schema distinguishes paper, experiment, missing, not reported, and extraction failed. | — |
| Learning exercise / Peter's quiz | Not created | NOT_STARTED | Peter's actual answers required | — |
| Founder paper digest | Not created | NOT_STARTED | Source/content and access checked | — |
| Branding pack | Not created | NOT_STARTED | Claims audited; drafted/public status distinct | — |
| Opportunity actions | Not created | NOT_STARTED | Drafted/sent/replied/booked/held distinct | — |
| Question / metric | Dataset, N and unit | Split / seed / config | Command or verification method | Output path and measured value | Uncertainty / limitation |
|---|---|---|---|---|---|
| Date | Action / counterpart | Receipt or private reference | State | Next action / date |
|---|---|---|---|---|
Peter's teach-back / quiz score: not assessed. Scientific assumptions and deviations: none recorded yet. Budget allocated / spent: not assessed / no spend recorded. Missing evidence and responsible owner: pending inspection.
Do not put API keys, source full texts with restricted rights, client data or invoice personal details in a public version of this register. Keep private evidence references private.
Review status: NOT_REVIEWED. Specification · Evidence
What Peter can explain or reproduce now: not assessed. Quiz / teach-back gaps: not assessed. Measured result and limitations: pending. Best evidence link for a scientist/recruiter/buyer: pending. What failed or changed, and why: pending.
Gate requirement: No standalone gate; check this week's acceptance criteria and next gate dependencies. Gate status: NOT_STARTED. Original target week: See next gate in specs. Actual completion date / forecast: not set. Missing external evidence: pending inspection. Blocks completed / 7: not recorded. Days with commits / 7: not recorded. Sunday build log / optional Wednesday note: not recorded. Founder conversations cumulative: not recorded. Earned evidence level and proof: not assessed. Consecutive lost weeks: not assessed.
Week-specific risk to revisit: Do not equate search hits with fermentation experiments. Scientific Data claims and company gaps are hypotheses. Freeze paper-level development/test partitions before annotation or prompt tuning.
Continue / recover / blocked: not decided.
Retain as the minimum: RELATED.md. If someone did it already, you must know now.
Skipped permanently with reason: none recorded.
Carryover with owner, dependency and target week: none recorded.
Canonical repository paths and versions: pending.
Data permissions, split definitions or assumptions to preserve: pending.
External action authorization that still applies: not assessed.
Next physical action, exact file/function/paragraph: pending.
Updates to root PROGRESS / LOG / TODAY completed: ☐
YOUR SPACE