Walk into a microbiology lab and you will see plate readers: machines that measure 96 or 384 tiny wells every few minutes. Out comes a spreadsheet with thousands of numbers, and someone spends an afternoon in Excel fitting curves by eye. The plate module ends that afternoon. Growth curves (the same lag-log-stationary story from week 1, now in tiny wells), dose-response curves (how much of a compound it takes to halv…
If you only do one thing this week: growth-curve fits with intervals
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering"
Saturday sandbox
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering", Nature Methods 16:687-694. The classic review; read it before week 21