Picture an agronomist with 40 spreadsheets from three seasons of field trials, each formatted by a different intern, and an investor asking "does your biological product actually increase yield, and by how much?". The honest answer requires a design (which plots got which treatment, in which block), a statistical model that respects that design, and an interval. Most startups answer with an average and a hopeful cha…
If you only do one thing this week: one published trial reproduced with an interval
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering"
Saturday sandbox
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering", Nature Methods 16:687-694. The classic review; read it before week 21