Until now you trained a detective on a general catalogue of fingerprints. This week you go to the partner's neighbourhood. Extremophiles live where most life would die: boiling springs, salt flats, Antarctic ice. Their enzymes are tough, which is exactly what industry wants (a detergent enzyme that works in hot water, a process enzyme that survives a 70 °C reactor). You pull sequences from UniProt for the partner's …
If you only do one thing this week: the ranked list sent
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering"
Saturday sandbox
Yang, Wu & Arnold (2019), "Machine-learning-guided directed evolution for protein engineering", Nature Methods 16:687-694. The classic review; read it before week 21